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Figure 5 | Reproductive Biology and Endocrinology

Figure 5

From: Luteal and placental function in the bitch: spatio-temporal changes in prolactin receptor (PRLr) expression at dioestrus, pregnancy and normal and induced parturition

Figure 5

Immunohistochemical (IHC) localization of PRLr in the uterus pre-implantation and in the utero/placental compartment. (A, B) IHC localization of PRLr in canine endometrium at the pre-implantation stage of pregnancy. (C, D) IHC localization of PRLr within the utero/placental compartment (mid-gestation). (E, F) Localization of PRLr-mRNA in utero/placental compartment by in situ hybridization (ISH).

(A, B) Pre-implantation PRLr is localized to the endometrial surface epithelial cells (solid arrowheads) and glandular epithelial cells of the superficial (open arrowheads) and deep (solid arrows) uterine glands. (C, D) Within the utero/placental compartment signals are localized to the endometrial glands including the superficial glands (solid arrowheads) (the so-called glandular chambers) and to the fetal trophoblast cells (open arrows). (E, F) The same localization pattern was observed at the mRNA-level by ISH. Thus, strong signals are localized to the trophoblast cells (open arrows) including those strongly invading maternal blood vessels at the base of placental labyrinth (open arrows).

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