Comparative gene expression profiling of placentas from patients with severe pre-eclampsia and unexplained fetal growth restriction

Table 4 The most highly differentially expressed genes common to pre-eclampsia and FGR

Gene name	Genbank	Fold-Change (PE)	PValue (PE)	Fold-Change (FGR)	PValue (FGR)
Up-regulated genes
LEP	NM_000230	10.94	<0.0001	3.56	0.0066
CGB	NM_000737	4.72	0.0011	2.50	0.0391
CGB5	NM_033043	4.71	0.0012	2.46	0.0436
CGB1	NM_033377	4.61	0.0010	2.38	0.0430
CGB7	NM_033142	4.43	0.0012	2.37	0.0445
CGB2	NM_033378	4.37	0.0007	2.37	0.0329
HTRA4	NM_153692	4.00	0.0002	1.93	0.0471
CRH	NM_000756	3.66	0.0008	2.36	0.0191
PAPPA2	NM_020318	2.55	0.0001	1.72	0.0125
NTRK2	NM_006180	2.50	<0.0001	1.58	0.0111
CP	NM_000096	2.44	0.0445	2.44	0.0446
FLT1	NM_002019	2.39	0.0001	1.51	0.0347
HTRA1	NM_002775	2.20	0.0015	1.67	0.0276
QPCT	NM_012413	2.12	0.0008	1.60	0.0240
ENG	NM_000118	2.03	0.0003	1.56	0.0143
Down-regulated genes
ACOXL	NM_001105516	2.39	<0.0001	1.92	0.0003
GSTA3	NM_000847	2.09	0.0014	1.60	0.0318
HIST1H1T	NM_005323	2.06	0.0003	2.03	0.0004
FAM26D	NM_153036	2.05	0.0009	1.83	0.0040
SNORD116	AF241255	1.98	0.0203	2.07	0.0140
CATSPERB	NM_024764	1.98	0.0001	1.66	0.0023
WNT2	NM_003391	1.97	0.0023	1.58	0.0301
MUC15	NM_145650	1.89	0.0024	1.52	0.0371
SH3TC2	NM_024577	1.89	0.0012	1.63	0.0092
C12orf39	BC004336	1.85	0.0044	1.55	0.0366
TMEM136	NM_174926	1.84	<0.0001	1.61	0.0007
ZNF554	NM_001102651	1.76	0.0005	1.71	0.0009
APLN	NM_017413	1.76	0.0007	1.65	0.0020
NAALADL2	NM_207015	1.73	0.0039	1.71	0.0045
ZNF429	NM_001001415	1.70	0.0027	1.56	0.0096

ISSN: 1477-7827