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Table 3 Association between CYP1B1 Leu/Val polymorphism and EM levels in breast tissue and urine

From: Comparison of estrogens and estrogen metabolites in human breast tissue and urine

BREAST TISSUE pg/g wet tissue CYP1B1 Leu/Leu Mean (SE) CYP1B1 Leu/Val+ Val/Val Mean (SE) p-value (Kruskal-Wallis test)
Estrogens# 373.7 (46.2) 117 (28) 0.02
2-hydroxylation Pathway 54.7 (22.9) 43.9 (8.3) 0.79
16-hydroxylation Pathway 141.8 (29.7) 76.1 (13.2) 0.07
Total* 570.5 (85.7) 237.0 (25.2) 0.02
2/16 ratio 0.39 (0.15) 0.73 (0.24) 0.31
URINE pg/mL    
Estrogens 37.4 (11.7) 124.3 (81.2) 0.79
2-hydroxylation Pathway 73.3 (39.6) 56.1 (19.2) 0.6
16-hydroxylation Pathway 216.6 (81.5) 151.5 (84) 0.3
Total 341.8 (132.3) 335.5 (149.1) 0.6
2/16 ratio 0.34 (0.09) 0.54 (0.16) 0.43
  1. *P value test for trend = 0.05
  2. #P value test for trend 0.06