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Table 3 Association between CYP1B1 Leu/Val polymorphism and EM levels in breast tissue and urine

From: Comparison of estrogens and estrogen metabolites in human breast tissue and urine

BREAST TISSUE

pg/g wet tissue

CYP1B1

Leu/Leu

Mean (SE)

CYP1B1

Leu/Val+ Val/Val

Mean (SE)

p-value

(Kruskal-Wallis test)

Estrogens#

373.7 (46.2)

117 (28)

0.02

2-hydroxylation Pathway

54.7 (22.9)

43.9 (8.3)

0.79

16-hydroxylation Pathway

141.8 (29.7)

76.1 (13.2)

0.07

Total*

570.5 (85.7)

237.0 (25.2)

0.02

2/16 ratio

0.39 (0.15)

0.73 (0.24)

0.31

URINE pg/mL

   

Estrogens

37.4 (11.7)

124.3 (81.2)

0.79

2-hydroxylation Pathway

73.3 (39.6)

56.1 (19.2)

0.6

16-hydroxylation Pathway

216.6 (81.5)

151.5 (84)

0.3

Total

341.8 (132.3)

335.5 (149.1)

0.6

2/16 ratio

0.34 (0.09)

0.54 (0.16)

0.43

  1. *P value test for trend = 0.05
  2. #P value test for trend 0.06