From: Comparison of estrogens and estrogen metabolites in human breast tissue and urine
BREAST TISSUE pg/g wet tissue | CYP1B1 Leu/Leu Mean (SE) | CYP1B1 Leu/Val+ Val/Val Mean (SE) | p-value (Kruskal-Wallis test) |
---|---|---|---|
Estrogens# | 373.7 (46.2) | 117 (28) | 0.02 |
2-hydroxylation Pathway | 54.7 (22.9) | 43.9 (8.3) | 0.79 |
16-hydroxylation Pathway | 141.8 (29.7) | 76.1 (13.2) | 0.07 |
Total* | 570.5 (85.7) | 237.0 (25.2) | 0.02 |
2/16 ratio | 0.39 (0.15) | 0.73 (0.24) | 0.31 |
URINE pg/mL | Â | Â | Â |
Estrogens | 37.4 (11.7) | 124.3 (81.2) | 0.79 |
2-hydroxylation Pathway | 73.3 (39.6) | 56.1 (19.2) | 0.6 |
16-hydroxylation Pathway | 216.6 (81.5) | 151.5 (84) | 0.3 |
Total | 341.8 (132.3) | 335.5 (149.1) | 0.6 |
2/16 ratio | 0.34 (0.09) | 0.54 (0.16) | 0.43 |