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Table 2 Mean values of relative estrogen metabolites measured in breast tissue and corresponding urines

From: Comparison of estrogens and estrogen metabolites in human breast tissue and urine

ESTROGEN METABOLITES (% of total estrogen) BREAST TISSUE Mean ± SD URINE Mean ± SD P value (Kruskal-Wallis test)
Estrogens (estrone, 17β-estradiol) 53.4 ± 19.0 20.5 ± 18.4 0.02
2-Hydroxylation Pathway (*) 15.6 ± 8.7 21.4 ± 10.3 0.4
16-Hydroxylation Pathway (**) 30.9 ± 14.7 55.4 ± 17.8 0.02
4-hydroxyestrone ( # ) -- 2.7 ± 2.0 N/A
2/16 ratio 0.61 ± 0.5 0.47 ± 0.34 0.45
  pg/g wet tissue pg/mL  
TOTAL 348.1 ± 188.8 337.4 ± 310.7 0.45
  1. *2-hydroxyestrone-3-methyl ether was not detected in breast tissue or urine
  2. **16-keto-17β-estradiol, 16-epiestriol were not detected in breast tissue or urine
  3. #4-methoxyestrone, 4-methoxy-17β-estradiol were not detected in breast tissue or urine