Figure 4From: Arsenic abrogates the estrogen-signaling pathway in the rat uterusImmunohistochemical localization of estrogen receptor in the rat uterine sections. Rats were treated with arsenic for 28 days and tissues were stained for the presence of the estrogen receptor. Arsenic significantly downregulated the estrogen receptors in the endometrial stroma (4b) as compared to the untreated uterus (4a). In addition, the expression of estrogen receptors was also decreased in the longitudinal muscle layer (4d) in contrast to the expression in the muscle layer of the control uterus (4c).Back to article page