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Figure 3 | Reproductive Biology and Endocrinology

Figure 3

From: Arsenic abrogates the estrogen-signaling pathway in the rat uterus

Figure 3

Alterations in tissue architecture of arsenic-treated rat uterus. Rats were treated with or without 4 μg/ml arsenic for 28 days. 3a, 3c, 3e and 3g: control sections; 3b, 3d, 3f and 3h: arsenic-treated sections. Uterine sections were subjected to double staining with hematoxylin and eosin and examined under the microscope. (3a, 3b) A significant decrease in width and invaginations of the arsenic-treated uterine lumen was observed in the treated sections (10× magnification) as compared to untreated one. (3c, 3d) Reduction in the height of luminal epithelial cells (as measured by occulometry) in the arsenic-treated sections was observed as compared to untreated one (40×). In addition, degeneration of the layer was also noted in the treated uterus. (3e, 3f) Arsenic treatment resulted in a significant reduction in the size of endometrial glands, with disappearance of the lumen and disorganization of the epithelial cells lining the glands. (3g, 3h) As compared to the control uterus, significant reduction in size and organization of the longitudinal muscle layer was observed in the arsenic-treated uterine sections.

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