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Figure 3 | Reproductive Biology and Endocrinology

Figure 3

From: Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium

Figure 3

Bioinformatic pathway and protein-protein interaction between PAFR-BRCA1. (A). Pathway Studio software (Ariadne Inc.) and Human ResNet Mammalian Database were used in the study. Antibody microarray based protein kinase profiling and identification of STAT1 and STAT4 in BRCA1-mutant and PAFR-over expression (PAFR+) ovarian epithelial cancer cells. UWB1 cells were treated with PAF (100 nM) for 24 hours. Images of kinase arrays of signals after the incubation with 310 μg protein lysate of UWB1 cells treated with 100 nM PAF only (B) or with combination of 100 μM ginkgolide B (GB) and 100 nM PAF (C). The duplicated internal positive controls were used to calibrate the detection signal of membranes of the treated and untreated experiments. The summary of kinase expression profile of the UWB1 cells with different treatments and significance comparison by the paired student t-test (D).

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