| | |
5 weeks of age
|
8 weeks of age
|
12 weeks of age
|
16 weeks of age
|
|---|
|
Body weight (g)
|
lean
|
80.32 +/- 5.80c
|
128.15 +/- 5.30c
|
151.61 +/- 8.83c
|
171.39 +/- 11.34
|
| |
fa/fa
|
108.13 +/- 6.78a,c
|
224.36 +/- 4.46a,c
|
282.10 +/- 14.61a,c
|
340.85 +/- 18.38a
|
|
% of irregular estrous cycle
|
lean
|
ND
|
0 (0/6)
|
0 (0/6)
|
0 (0/6)
|
| |
fa/fa
|
ND
|
14.3%(0/6)
|
28.6% (0/6)
|
71.4% (0/6)
|
|
FSH (ng/ml)
|
lean
|
ND
|
5.07 +/- 0.06
|
3.01 +/- 0.22
|
4.63 +/- 0.65
|
| |
fa/fa
|
ND
|
5.15 +/- 0.21
|
2.87 +/- 0.45
|
3.81 +/- 0.74
|
|
LH (ng/ml)
|
lean
|
ND
|
0.97 +/- 0.23
|
1.10 +/- 0.14
|
1.03 +/- 0.18
|
| |
fa/fa
|
ND
|
1.15 +/- 0.57
|
1.57 +/- 0.18
|
1.21 +/- 0.23
|
|
Estradiol (pg/ml)
|
lean
|
ND
|
13.26 +/- 1.57d
|
24.45 +/- 1.41c
|
65.51 +/- 18.07
|
| |
fa/fa
|
ND
|
8.53 +/- 0.29b,d
|
14.38 +/- 0.98a
|
17.70 +/- 1.47a
|
|
Testosterone (ng/ml)
|
lean
|
0.16 +/- 0.04c
|
0.45 +/- 0.02
|
0.44 +/- 0.08
|
0.35 +/- 0.16
|
| |
fa/fa
|
0.07 +/- 0.01c
|
0.34 +/- 0.12d
|
0.28 +/- 0.14b,d
|
0.16 +/- 0.05b
|
|
Androstendione (ng/ml)
|
lean
|
0.70 +/- 0.35c
|
1.50 +/- 0.46
|
1.55 +/- 0.52
|
1.35 +/- 0.52
|
| |
fa/fa
|
0.13 +/- 0.06b,c
|
0.65 +/- 0.12b,d
|
0.53 +/- 0.22a,c
|
0.33 +/- 0.15a
|
- Rats were usually sacrificed by decapitation on day 4 of their estrous cycle, in diestrus during day, and after 12 h of fasting (5, 8, 12 and 16 weeks of age). Data are presented as means ± SD; n = 6 or 7 in each group. a: P < 0.01, b: P < 0.05 vs. lean rats, c: P < 0.01, d: P < 0.05 vs. later weeks, ND: not done.
