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Table 2 Summary of body weights, estrous cycle and hormonal data for Zucker fa/fa and lean rats

From: Remarkable features of ovarian morphology and reproductive hormones in insulin-resistant Zucker fatty (fa/fa) rats

   5 weeks of age 8 weeks of age 12 weeks of age 16 weeks of age
Body weight (g) lean 80.32 +/- 5.80c 128.15 +/- 5.30c 151.61 +/- 8.83c 171.39 +/- 11.34
  fa/fa 108.13 +/- 6.78a,c 224.36 +/- 4.46a,c 282.10 +/- 14.61a,c 340.85 +/- 18.38a
% of irregular estrous cycle lean ND 0 (0/6) 0 (0/6) 0 (0/6)
  fa/fa ND 14.3%(0/6) 28.6% (0/6) 71.4% (0/6)
FSH (ng/ml) lean ND 5.07 +/- 0.06 3.01 +/- 0.22 4.63 +/- 0.65
  fa/fa ND 5.15 +/- 0.21 2.87 +/- 0.45 3.81 +/- 0.74
LH (ng/ml) lean ND 0.97 +/- 0.23 1.10 +/- 0.14 1.03 +/- 0.18
  fa/fa ND 1.15 +/- 0.57 1.57 +/- 0.18 1.21 +/- 0.23
Estradiol (pg/ml) lean ND 13.26 +/- 1.57d 24.45 +/- 1.41c 65.51 +/- 18.07
  fa/fa ND 8.53 +/- 0.29b,d 14.38 +/- 0.98a 17.70 +/- 1.47a
Testosterone (ng/ml) lean 0.16 +/- 0.04c 0.45 +/- 0.02 0.44 +/- 0.08 0.35 +/- 0.16
  fa/fa 0.07 +/- 0.01c 0.34 +/- 0.12d 0.28 +/- 0.14b,d 0.16 +/- 0.05b
Androstendione (ng/ml) lean 0.70 +/- 0.35c 1.50 +/- 0.46 1.55 +/- 0.52 1.35 +/- 0.52
  fa/fa 0.13 +/- 0.06b,c 0.65 +/- 0.12b,d 0.53 +/- 0.22a,c 0.33 +/- 0.15a
  1. Rats were usually sacrificed by decapitation on day 4 of their estrous cycle, in diestrus during day, and after 12 h of fasting (5, 8, 12 and 16 weeks of age). Data are presented as means ± SD; n = 6 or 7 in each group. a: P < 0.01, b: P < 0.05 vs. lean rats, c: P < 0.01, d: P < 0.05 vs. later weeks, ND: not done.