From: Characterization of a diverse secretome generated by the mouse preimplantation embryo in vitro
Protein name | Common Name | Gene Name | Main Function, where known |
---|---|---|---|
Essential for preimplantation development | Â | Â | Â |
NLR family, pyrin domain containing 5 | Mater | Nlrp5 | Cell surface expression protein essential for normal early embryo development |
Peptidyl arginine deiminase, type VI | ePAD | Padi6 | Catalyzes the deimination of arginine residues of proteins. May be involved in cytoskeletal reorganization in the egg and early embryo. |
Modification of proteins | Â | Â | Â |
Peptidylprolyl isomerase A | cyclophilin A | Ppia | Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, accelerates the folding of proteins. |
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta/delta polypeptide | 14-3-3 zeta | Ywhaz | Adapter protein that binds to a large number of partners by recognition of a phosphoserine or phosphothreonine motif. Generally results in the modulation of the activity of the binding partner. |
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | 14-3-3 gamma | Ywhag | As above. |
REDOX regulation | Â | Â | Â |
Lactate dehydrogenase B | LHD-2 | Ldhb | Catalyzes reaction: (S)-lactate + NAD(+) = pyruvate + NADH. |
Prolyl 4-hydroxylase, beta polypeptide (ERp59) | Protein disulfide-isomerase | P4hb | Catalyzes the formation, breakage and rearrangement of disulfide bonds. Present at high levels in many cells and actively shed by many cells. |
Protein disulfide-isomerase A3 (ERp61) | Protein disulfide-isomerase | Pdia3 | Catalyzes the formation, breakage and rearrangement of disulfide bonds |
Peroxiredoxin 1 | Thioredoxin peroxidase 2 | Prdx1 | Catalyzes reactions: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH. |
Chaperonins | Â | Â | Â |
Calreticulin | Calregulin | Calr | Calcium binding chaperonin, promotes protein folding. Can act as a cell surface lectin. |
Heat shock protein HSP 90-alpha | HSP 90 | Hsp90aa1 | A stress actvated chaperonin with ATPase activity. Many cellular functions and targets. |
2'-5' oligoadenylate synthetase 1C | Â | Oas1c | Interferon activated anti-viral agent |
Miscellaneous or Ill-defined function | Â | Â | Â |
Spindlin isoform 1 | 30000 metaphase complex | Spin1 | A meiotic spindle binding protein present in oocytes. |
Glycogenin 1 | Â | Gyg1 | Self-glucosylates forming oligosaccharide primer for glycogen synthase |
Transducin-like enhancer of split 6 | Groucho-related protein 6 | Tle6 | Transcriptional co-repressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. |
2,3-bisphosphoglycerate mutase | 2,3-bisphosphoglycerate synthase | Bpgm | Regulates hemoglobin oxygen affinity. Catalyzes reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate. |
Phosphatidylethanolamine binding protein | HCNPpp | Pebp1 | Binds ATP, opioids and phosphatidylethanolamine. Serine protease inhibitor, may be involved in the function of the pre-synaptic cholinergic neurons of the central nervous system. |
Zinc finger, BED domain containing 3 | Â | Zbed3 | Still to be defined, transcripts detected in 2-cell embryo library |
F-box domain containing protein | Â | Â | F-box domain is approximately 50 amino acids long and is found in the N-terminal half of a variety of proteins commonly associated with the leucine rich repeats |
Oviductal glycoprotein 1 | OGP | Ovgp1 | Belongs to the glycosyl hydrolase 18 family. Released by oviduct, binds to zona pelleucida. |