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Table 1 Human SIZP mediated induction of acrosome reaction in capacitated human sperm

From: Delineation of downstream signalling components during acrosome reaction mediated by heat solubilized human zona pellucida

Treatment

Percent induction of acrosomal exocytosis (Mean ± SEM)

Statistical significance

Experiment I a

  

PBS Control

13.7 ± 1.4

 

SIZP (~1 zona)

26.3 ± 1.4

p = 0.003c

SIZP (~2 zonae)

29.4 ± 0.4

p = 0.009c

SIZP (~5 zonae)

39.7 ± 1.7

p = 0.0003c

SIZP (~10 zonae)

36.4 ± 0.9

p = 0.0009c

Experiment II b

  

PBS control

14.7 ± 1.3

 

PBS + SIZP (~5 zonae)

36.1 ± 3.1

p = 0.007c

Calcium ionophore (10 μM)

56.1 ± 4.5

p = 0.0001c

  1. aSIZP mediated acrosome reaction was studied by employing semen samples from three different donors
  2. bSIZP mediated acrosome reaction was studied by employing semen samples from six different donors
  3. cValues are statistically significant as compared to respective PBS control
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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