Figure 3

Ovary and liver weights of WT, Smad2^flox/-; Inha^-/-control (Con) and Smad2^flox/-; Inha^-/-; Amhr2^cre/+( S2/Inha cKO) experimental mice. Note the dramatic alteration of the weights of the ovary and liver of the Smad2^flox/-; Inha^-/-(6-26 wk; n = 11) and Smad2^flox/-; Inha^-/-; Amhr^cre/+(6-23 wk; n = 5) mice compared to adult WT mice (12 wk; n = 5) due to tumor development. However, no differences in the ovary and liver weights were observed between the control and S2/Inha cKO mice. All data are shown as mean ± SEM, and bars without a common letter are significantly different at P < 0.01.