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Table 2 Classification of MAA responsive genes by duration of MAA treatment required to elicit response

From: Impact of methoxyacetic acid on mouse Leydig cell gene expression

Group Sub-group 3 h MAA 8 h MAA 24 h MAA Genes in each subgroup (number)
Early (1366 genes) early transient up Up - - 351
  early transient up Up - Up 26
  early sustained up Up Up - 149
  early persistent up Up Up Up 223
  early transient down Down - - 245
  early transient down Down - Down 20
  early sustained down Down Down - 198
  early persistent down Down Down Down 154
Mid (1387 genes) mid transient up - Up - 344
  mid sustained up - Up Up 466
  mid transient down - Down - 395
  mid sustained down - Down Down 182
Late (1138 genes) late up - - Up 775
  late down - - Down 363
  1. The 5 mM MAA-responsive genes were divided into 3 groups, early response (3 h), mid response (8 h) and late response (24 h) based on the minimum period of MAA exposure that was required to evoke a gene response compared to control cells. The direction of response is indicated as Up (up-regulation), Down (down-regulation) or - (no significant response). 21 other genes that did not meet these MAA response criteria are shown in Additional file 2.