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Table 2 Classification of MAA responsive genes by duration of MAA treatment required to elicit response

From: Impact of methoxyacetic acid on mouse Leydig cell gene expression

Group

Sub-group

3 h MAA

8 h MAA

24 h MAA

Genes in each subgroup (number)

Early (1366 genes)

early transient up

Up

-

-

351

 

early transient up

Up

-

Up

26

 

early sustained up

Up

Up

-

149

 

early persistent up

Up

Up

Up

223

 

early transient down

Down

-

-

245

 

early transient down

Down

-

Down

20

 

early sustained down

Down

Down

-

198

 

early persistent down

Down

Down

Down

154

Mid (1387 genes)

mid transient up

-

Up

-

344

 

mid sustained up

-

Up

Up

466

 

mid transient down

-

Down

-

395

 

mid sustained down

-

Down

Down

182

Late (1138 genes)

late up

-

-

Up

775

 

late down

-

-

Down

363

  1. The 5 mM MAA-responsive genes were divided into 3 groups, early response (3 h), mid response (8 h) and late response (24 h) based on the minimum period of MAA exposure that was required to evoke a gene response compared to control cells. The direction of response is indicated as Up (up-regulation), Down (down-regulation) or - (no significant response). 21 other genes that did not meet these MAA response criteria are shown in Additional file 2.