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Table 2 Area under the ROC curves (AuROC) and associations between serum Relaxin, TIMP-2 and relaxin:TIMP-2 ratios and a history of RPL

From: Circulating levels of matrix proteases and their inhibitors in pregnant women with and without a history of recurrent pregnancy loss

  AuROC (95% CI) P value Optimal predictive
cut-off value
Sensitivity (95% CI) Specificity (95% CI) +LR (95% CI) -LR (95% CI)
6-8 wks gestation        
Relaxin (ng/ml) 0.65 (0.50 - 0.80) < 0.05 < = 1.3 80.00 (56.3 - 94.3) 46.67 (21.3 - 73.4) 1.50 (0.8 - 2.7) 0.43 (0.2 - 1.2)
TIMP-2 (ng/ml) 0.84 (0.60 - 0.97) < 0.001 > 14 77.78 (40.0 - 97.2) 70.00 (34.8 - 93.3) 2.59 (1.5 - 4.4) 0.32 (0.07 - 1.5)
Relaxin:TIMP-2 ratio 0.89 (0.67-0.99) < 0.0001 <= 0.06 77.78 (40.0 - 97.2) 90.00 (55.5 - 99.7) 7.78 (5.2 - 11.7) 0.25 (0.03 - 2.3)
10-12 wks gestation        
Relaxin (ng/ml) 0.73 (0.54 - 0.90) < 0.05 <= 1.7 95.00 (75.1 - 99.9) 42.11 (20.3 - 66.5) 1.64 (1.0 - 2.8) 0.12 (0.02 - 0.8)
TIMP-2 (ng/ml) 0.83 (0.63 - 0.95) < 0.001 > 10 75.00 (42.8 - 94.5) 83.33 (51.6 - 97.9) 4.50 (3.0 - 6.8) 0.30 (0.06 - 1.5)
Relaxin:TIMP-2 ratio 0.92 (0.74 - 0.99) < 0.0001 <= 0.09 100.00 (73.5 - 100.0) 75.00 (42.8 - 94.5) 4.00 (2.9 - 5.5) 0.00 (0.01 - 0.9)
20 weeks gestation        
Relaxin (ng/ml) 0.77 (0.58 - 0.90) < 0.01 <= 0.71 78.95 (54.4 - 93.9) 61.11 (35.7 - 82.7) 2.03 (1.3 - 3.1) 0.34 (0.1 - 1.0)
TIMP-2 (ng/ml) 0.73 (0.52 - 0.88) < 0.05 > 20 50.00 (21.1 - 78.9) 100.00 (78.2 - 100.0)   0.50
Relaxin:TIMP-2 ratio 0.81(0.61-0.93) < 0.001 <= 0.05 66.67 (34.9 - 90.1) 80.00 (51.9 - 95.7) 3.33 (2.1 - 5.4) 0.42 (0.1 - 1.5)
34 weeks gestation        
Relaxin (ng/ml) 0.68 (0.48 - 0.84) 0.13 <= 0.9 94.44 (72.7 - 99.9) 47.06 (23.0 - 72.2) 1.78 (1.1 - 3.0) 0.12 (0.02 - 0.8)
TIMP-2 (ng/ml) 0.67 (0.46 - 0.85) 0.11 >14 66.67 (34.9 - 90.1) 30.77 (9.1 - 61.4) 0.96 (0.4 - 2.4) 1.08 (0.5 - 2.6)
Relaxin:TIMP-2 ratio 0.77 (0.56- 0.92) <0.01 <= 0.04 83.33 (51.6 - 97.9) 76.92 (46.2 - 95.0) 3.61 (2.4 - 5.3) 0.22 (0.04 - 1.1)
Umbilical cord levels        
Relaxin (ng/ml) 0.52(0.32 - 0.71) NS      
TIMP-2 (ng/ml) 0.50 (0.28 - 0.72) NS      
Relaxin:TIMP-2 ratio 0.56 (0.32-0.78) NS      
  1. NS: not significant.