Table 2 Area under the ROC curves (AuROC) and associations between serum Relaxin, TIMP-2 and relaxin:TIMP-2 ratios and a history of RPL

6-8 wks gestation

Relaxin (ng/ml)

0.65 (0.50 - 0.80)

< 0.05

< = 1.3

80.00 (56.3 - 94.3)

46.67 (21.3 - 73.4)

1.50 (0.8 - 2.7)

0.43 (0.2 - 1.2)

TIMP-2 (ng/ml)

0.84 (0.60 - 0.97)

< 0.001

> 14

77.78 (40.0 - 97.2)

70.00 (34.8 - 93.3)

2.59 (1.5 - 4.4)

0.32 (0.07 - 1.5)

Relaxin:TIMP-2 ratio

0.89 (0.67-0.99)

< 0.0001

<= 0.06

77.78 (40.0 - 97.2)

90.00 (55.5 - 99.7)

7.78 (5.2 - 11.7)

0.25 (0.03 - 2.3)

10-12 wks gestation

Relaxin (ng/ml)

0.73 (0.54 - 0.90)

< 0.05

<= 1.7

95.00 (75.1 - 99.9)

42.11 (20.3 - 66.5)

1.64 (1.0 - 2.8)

0.12 (0.02 - 0.8)

TIMP-2 (ng/ml)

0.83 (0.63 - 0.95)

< 0.001

> 10

75.00 (42.8 - 94.5)

83.33 (51.6 - 97.9)

4.50 (3.0 - 6.8)

0.30 (0.06 - 1.5)

Relaxin:TIMP-2 ratio

0.92 (0.74 - 0.99)

< 0.0001

<= 0.09

100.00 (73.5 - 100.0)

75.00 (42.8 - 94.5)

4.00 (2.9 - 5.5)

0.00 (0.01 - 0.9)

20 weeks gestation

Relaxin (ng/ml)

0.77 (0.58 - 0.90)

< 0.01

<= 0.71

78.95 (54.4 - 93.9)

61.11 (35.7 - 82.7)

2.03 (1.3 - 3.1)

0.34 (0.1 - 1.0)

TIMP-2 (ng/ml)

0.73 (0.52 - 0.88)

< 0.05

> 20

50.00 (21.1 - 78.9)

100.00 (78.2 - 100.0)

0.50

Relaxin:TIMP-2 ratio

0.81(0.61-0.93)

< 0.001

<= 0.05

66.67 (34.9 - 90.1)

80.00 (51.9 - 95.7)

3.33 (2.1 - 5.4)

0.42 (0.1 - 1.5)

34 weeks gestation

Relaxin (ng/ml)

0.68 (0.48 - 0.84)

0.13

<= 0.9

94.44 (72.7 - 99.9)

47.06 (23.0 - 72.2)

1.78 (1.1 - 3.0)

0.12 (0.02 - 0.8)

TIMP-2 (ng/ml)

0.67 (0.46 - 0.85)

0.11

>14

66.67 (34.9 - 90.1)

30.77 (9.1 - 61.4)

0.96 (0.4 - 2.4)

1.08 (0.5 - 2.6)

Relaxin:TIMP-2 ratio

0.77 (0.56- 0.92)

<0.01

<= 0.04

83.33 (51.6 - 97.9)

76.92 (46.2 - 95.0)

3.61 (2.4 - 5.3)

0.22 (0.04 - 1.1)

Umbilical cord levels

Relaxin (ng/ml)

0.52(0.32 - 0.71)

NS

TIMP-2 (ng/ml)

0.50 (0.28 - 0.72)

NS

Relaxin:TIMP-2 ratio

0.56 (0.32-0.78)

NS