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Figure 4 | Reproductive Biology and Endocrinology

Figure 4

From: Antiproliferative effect of growth hormone-releasing hormone (GHRH) antagonist on ovarian cancer cells through the EGFR-Akt pathway

Figure 4

JMR-132 attenuated the effect of EGF-induced p-Akt activation. A. p-Akt was activated after EGF (10 ng/ul) treatment without changes in Akt. β-actin was used as an internal control. B. p-Akt expression decreased after treatment with 100 nM JMR-132 per day for 2 and 4 days without changes in Akt level. C. JMR-132 attenuated the effect of EGF-induced p-Akt expression. JMR-132 (100 nM) and PI3K specific inhibitor LY294002 (10 nM) were used separately to continuously treat SKOV3 and CaOV3 cells for 2 days. PI3K specific inhibitor LY294002 was used as a positive control. β-actin was used as an internal control. EGF was added 15 min prior to harvesting.

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