Antiproliferative effect of JMR-132 on SKOV3 and CAOV3 cells. SKOV3 (2000/well) and CaOV3 (3000/well) were treated with JMR-132 at a different dose (25, 50, 100 and 200 nM) per day for 2 days (A), (C) and with 100 nM JMR-132 per day for different periods of time (24, 48, 72 and 96 h) (B) (D). MTT assay showed that proliferation was inhibited in a dose (A) and time (B) dependent manner after JMR-132 treatment. * P < 0.05 compared to the no treatment group. The expression of cleaved caspase3 increased in a dose (C) and time (D) dependent manner. The results indicated that JMR-132 treatment induced apoptosis in these cells.