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Table 2 Ovarian morphological parameters in rats following chemotherapy and pregnancy.

From: Assessment of fertility protection and ovarian reserve with GnRH antagonist in rats undergoing chemotherapy with cyclophosphamide

 

Group I

(placebo)

Group II

(CPA)

Group III

(GnRHant + CPA)

Group IV

(GnRHant)

Primordial and primary follicles

3.4 ± 0.53

2.9 ± 0.38

3.8 ± 0.46

3.8 ± 0.52

Preantral follicles

3.0 ± 0.24

3.4 ± 0.54

3.9 ± 0.48

4.1 ± 0.39

Antral follicles

4.4 ± 0.34

5.0 ± 0.60

6.6 ± 0.53

6.4 ± 0.50

Corpora lutea

4.2 ± 0.40

3.3 ± 0.50

3.4 ± 0.40

4.1 ± 0.30

Total number of follicles

10.9 ± 0.70

11.6 ± 1.14

14.3 ± 1.26

17.1 ± 1.22*

Ovarian cross-sectional area (mm2)

5.45 ± 0.50

4.30 ± 0.56

4.56 ± 0.89

4.62 ± 0.66

  1. Data are expressed as mean ± standard error. *p < 0.05 vs. Group I.
  2. CPA, cyclophosphamide; GnRHant, gonadotropin-releasing hormone antagonist (cetrorelix).