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Table 3 Genes associated with pulmonary development or surfactant that are modulated by sex and/or antiandrogen treatment

From: Gene expression profile of androgen modulated genes in the murine fetal developing lung

Process1 Symbol Gene name Modulation2
LUNG DEVELOPMENT REGULATORS
Shh signaling Gli1 GLI-Kruppel family member GLI1 17 m>17 f; 18 m>18 f
Shh signaling Gli3 GLI-Kruppel family member GLI3 17 m>17 f; 18 m>18 f
FGF signaling Fgf10 Fibroblast growth factor 10 17 m>17 f
TGF-β Signaling Tgfbr3 Transforming growth factor, beta re ceptor III 17 m>17 f
TGF-β Signaling Tsc22d1 TSC22 domain family, member 1 17 m>17 f
TGF-β Signaling Tgfb2 Transforming growth factor, beta 2 17 flut>17 m
BMP signaling Bmpr2 Bone morphogenic protein receptor, type II 17 m>17 f; 18 m>18 flut
BMP signaling Gdf10 Growth differentiation factor 10 17 m>17 flut
BMP signaling Gdf15 Growth differentiation factor 15 17 flut>17 m
Wnt signaling Gsk3b Glycogen synthase kinase 3 beta 17 m>17 f
Wnt signaling Ctnna1 Catenin (cadherin associated protein), alpha 1 17 m>17 f
Wnt signaling Tcf4 Transcription factor 4 17 m>17 f
Wnt signaling Crebbp CREB binding protein 17 m>17 f
SURFACTANT RELATED GENES
Phosphatidyl cholin synthesis Lpin2 Lipin 2 17 m>17 f; 18 m>18 f
Phosphatidyl cholin synthesis Chka Choline kinase alpha 17 m>17 f; 17 m>17 flut; 18 m>18 f; 18 m>18 flut
Phosphatidyl cholin synthesis Cds2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 18 flut>18 m
Phosphatidyl cholin synthesis Aytl2 (Lpcat1) Lysophosphatidylcholine acyltransferase 1 17 flut>17 m
Sphingolipids synthesis Mgll Monoglyceride lipase 17 f>17 m
Sphingolipids synthesis Aldh9a1 Aldehyde dehydrogenase 9, subfamily A1 17 f>17 m
Sphingolipids synthesis Pnliprp2 Pancreatic lipase-related protein 2 17 f>17 m
Sphingolipids synthesis Sgpp1 Sphingosine-1-phosphate phosphatase 1 17 f>17 m
Sphingolipids synthesis Dusp11 Dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 17 f>17 m
Sphingolipids synthesis Crls1 Cardiolipin synthase 1 17 f>17 m; 18 m>18 f
Sphingolipids synthesis Gba Glucosidase, beta, acid 17 f>17 m
Surfactant proteins Sftpa1 Surfactant associated protein A1 17 flut>17 m; 17 flut>17 f; 18 m>17 m; 18 f>17 f
Surfactant proteins Sftpb Surfactant associated protein B 17 flut>17 f; 18 m>17 m; 18 f>17 f
Surfactant proteins Sftpc Surfactant associated protein C 17 flut>17 f; 18 m>17 m; 18 f>17 f; 18 m>18 flut
Surfactant proteins Sftpd Surfactant associated protein D 18 m>17 m; 18 f>17 f
SURFACTANT REGULATION
Miscellaneous regulators Klf5 Kruppel-like factor 5 17 flut>17 m; 17 flut>17 f
Miscellaneous regulators Ltbp1 Latent transforming growth factor beta binding protein 1 17 m>17 f
Miscellaneous regulators Pten Phosphatase and tensin homolog 17 m>17 f; 17 m>17 flut
Miscellaneous regulators Magi1 Membrane associated guanylate kinase, WW and PDZ domain containing 1 17 m>17 f
Miscellaneous regulators Ptges2 Prostaglandin E synthase 2 17 f>17 m
IGF signaling Igfbp2 Insulin-like growth factor binding protein 2 17 m>17 flut
IGF signaling Igfbp5 Insulin-like growth factor binding protein 5 17 m>17 flut
IGF signaling Igf1 Insulin-like growth factor 1 17 m>17 flut
IGF signaling Igfr2 (Fcgr2b) Fc receptor, IgG, low affinity IIb 17 m>17 flut
  1. 1Shh: sonic hedgehog, FGF: fibroblast growth factor, TGF-β: transforming growth factor beta, BMP: bone morphogenetic protein, Wnt: wingless integration site, PC: phosphatidyl choline, IGF: insulin growth factor.
  2. 2Flut: flutamide treated males, m: males, f: females.