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Table 2 Genes related to hormones, lipid processing, and lung function that are modulated by sex and antiandrogen treatment

From: Gene expression profile of androgen modulated genes in the murine fetal developing lung

Biological function Gene symbol Gene name Expression pattern1
GESTATIONAL DAY 17
Steroid Hsd17b12 Hydroxysteroid (17-beta) dehydrogenase 12 #2 (m > flut > f)
Androgen Ext1 Exostoses (multiple) 1 #2 (m > flut > f)
Glucocorticoid Glcci1 Glucocorticoid induced transcript 1 #5 (m > f > flut)
Lipid binding Prkca Protein kinase c, alpha #5 (m > f > flut)
Lipid binding Ncam1 Neural cell adhesion molecule 1 #5 (m > f > flut)
Lipid binding Gpc6 Glypican 6 #2 (m > flut > f)
Steroid hormone receptor activity Nr6a1 Nuclear receptor subfamily 6, group a, member 1 #2 (m > flut > f)
Steroid hormone receptor activity Nr2c2 Nuclear receptor subfamily 2, group c, member 2 #2 (m > flut > f)
Cellular lipid metabolic process Sgpp1 Sphingosine-1-phosphate phosphatase 1 #2 (m > flut > f)
Cellular lipid metabolic process Pbx1 Pre b-cell leukemia transcription factor 1 #5 (m > f > flut)
Cellular lipid metabolic process Hsd17b12 Hydroxysteroid (17-beta) dehydrogenase 12 #2 (m > flut > f)
Cellular lipid metabolic process Hadhb Hydroxyacyl-coenzyme A dehydrogenase/3-ketoacyl-coenzyme A thiolase/enoyl-coenzyme A hydratase (trifunctional protein), beta subunit #2 (m > flut > f)
Cellular lipid metabolic process Ggtla1 Gamma-glutamyltransferase-like activity 1 #3 (flut > f > m)
Respiratory gaseous exchange Pbx3 Pre b-cell leukemia transcription factor 3 #2 (m > flut > f)
Respiratory tube development Nfib Nuclear factor i/b #2 (m > flut > f)
Respiratory tube development Foxp1 Forkhead box P1 #5 (m > f > flut)
Embryonic development Kif1b Kinesin family member 1b #2 (m > flut > f)
Embryonic development Ext1 Exostoses (multiple) 1 #2 (m > flut > f)
GESTATIONAL DAY 18
Lipid binding Rock1 Rho-associated coiled-coil forming kinase 1 #5 (m > f > flut)
Lipid binding Nr5a2 Nuclear receptor subfamily 5, group a, member 2 #5 (m > f > flut)
Steroid hormone receptor activity Nr5a2 Nuclear receptor subfamily 5, group a, member 2 #5 (m > f > flut)
Cellular lipid metabolic process Pip5k3 Phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III #4 (f > flut > m)
Cellular lipid metabolic process Pbx1 Pre b-cell leukemia transcription factor 1 #4 (f > flut > m)
Cellular lipid metabolic process Nr5a2 Nuclear receptor subfamily 5, group a, member 2 #5 (m > f > flut)
Cellular lipid metabolic process Idi1 Isopentenyl-diphosphate delta isomerase #2 (m > flut > f)
Cellular lipid metabolic process Elovl6 Elovl family member 6, elongation of long chain fatty acids (yeast) #2 (m > flut > f)
Cellular lipid metabolic process Dhcr24 24-dehydrocholesterol reductase #2 (m > flut > f)
Cellular lipid metabolic process Crls1 Cardiolipin synthase 1 #5 (m > f > flut)
Lipid transport Osbpl9 Oxysterol binding protein-like 9 #4 (f > flut > m)
Respiratory gaseous exchange Fut8 Fucosyltransferase 8 #4 (f > flut > m)
Respiratory tube development Gli1 Gli-kruppel family member gli1 #2 (m > flut > f)
  1. 1Genes are situated among their corresponding expression patterns presented in Table 1. Flut: flutamide treated males. m: males. f: females.