Association of ghrelin and leptin with reproductive hormones in constitutional delay of growth and puberty

Table 1 Subjects characteristics

Characteristics	Adolescents with CDGP (n = 23)	Normal control (n = 20)	P-value
Age (years)	15.1 + 0.67	15.1 + 0.72	0.9
Weight (kg)	38.5 + 3.1	64.3 + 13.36	< 0.001*
Standing height (cm)	147.8 + 5.9	169.55 + 9.9	< 0.001*
BMI (kg/m ² )	17.6 + 0.9	23.4 + 2.2	< 0.001*
Testicular volume (ml)	2.6 + 0.5	11.6 + 2	< 0.001*
Bone age (years)	12.7 + 0.5	15.1 + 0.67	< 0.001*
Bone age delay (years)	2.3 + 0.4	-
FSH (iu/ml)	0.4 + 0.08	5.1 + 0. 7	< 0.001*
LH (iu/ml)	0.2 + 0.06	4.3 + 0.7	< 0.001*
Testosterone (ng/ml)	0.06 + 0.02	4.5 + 3.2	< 0.001*
Leptin (ng/ml)	3.06 + 0.6	7.03 + 2.5	< 0.001*
Ghrelin (ng/ml)	276.4 + 58.9	106.5 + 29.6	< 0.001*

CDGP: Constitutional delay of growth and puberty; BMI: Body mass index; FSH: Follicle stimulating hormone; LH: Luteinizing hormone; Data are expressed as mean ± standard deviation; *P is significant if < 0.05

ISSN: 1477-7827