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Table 6 Pregnancy outcomes from the oocyte-retrieved cycles - age subgroups

From: In vitro fertilisation with recombinant follicle stimulating hormone requires less IU usage compared with highly purified human menopausal gonadotrophin: results from a European retrospective observational chart review

Characteristic rFSH hMG-HP Chi-square p-value
Total cycles started     
   (≤35 years) 15422 5142   
   (≥36 years) 7243 2823   
Number of total cycles with oocytes retrieved     
   (≤35 years) 15,293 (99.16%) 5,137 (99.90%) 32.55 <0.0001
   (≥36 years) 7174 (99.05%) 2821 (99.93%) 22.55 <0.0001
Cycles with positive pregnancy test as percent of cycles started     
   (≤35 years) 5,440 (35.27%) 1,741 (33.86%) 3.40 0.0651
   (≥36 years) 2157 (29.78%) 812 (28.76%) 1.01 0.3150
Cycles with positive pregnancy test as percent of cycles with oocyte retrieved     
   (≤35 years) 5,438 (35.56%) 1,739 (33.85%) 4.91 0.0267
   (≥36 years) 2157 (30.07%) 812 (28.78%) 1.60 0.2065
Any clinical pregnancy with positive pregnancy test     
   (≤35 years) 5302 (97.50%) 1739 (100%) 44.33 <0.0001
   (≥36 years) 2121 (98.33%) 811 (99.88%) 11.45 0.0007
Any clinical pregnancy as percent of cycles with oocyte retrieved     
   (≤35 years) 5302 (34.67%) 1739 (33.85%) 1.14 0.2864
   (≥36 years) 2121 (29.57%) 811 (28.75%) 0.65 0.4197
Pregnancies ending in spontaneous abortion as percent of cycles with oocyte retrieved     
   (≤35 years) 860 (6.00%) 297 (5.79%) 0.30 0.5841
   (≥36 years) 443 (6.48%) 181 (6.43%) 0.0071 0.9329
  1. Note: Cycles with positive pregnancy test were defined as cycles with a biochemical pregnancy and any clinical pregnancy. Clinical pregnancies were defined based on data entries 'clinical pregnancy', 'ongoing pregnancy', 'live birth', and 'spontaneous abortion'. Pregnancies ending in spontaneous abortion were defined as those with data entries 'spontaneous abortion' and 'miscarriage'
  2. † Due to lack of data on this outcome, only data for Germany and Denmark were considered here to calculate the percentage (N = 21,160 for rFSH subgroup; N = 7,940 for hMG-HP subgroup).