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Table 6 Detection rate for a fixed false-positive rate: Modelled results

From: First trimester screening for trisomy 21 in gestational week 8-10 by ADAM12-S as a maternal serum marker

  DR
(i) maternal age, PAPP-A & free B-hCG 78.5
(ii) maternal age, PAPP-A, free B-hCG & ADAM12-S 78.6
(iii) maternal age, PAPP-A, free B-hCG & NT 91.6
(iv) maternal age, PAPP-A, free B-hCG, NT & ADAM12-S 91.7
(v) maternal age, PAPP-A & ADAM12-S 71.0
(vi) maternal age, PAPP-A, ADAM12-S & NT 88.9
  1. Results for first trimester screening test with and without ADAM12-S. Modelled detection rates for fetal trisomy 21 at a fixed false-positive rate of 5%.
  2. Virtually no change in DR when ADAM12-S is added to first trimester biochemistry and when ADAM12-S is added to the combined test.
  3. Substantial reduction in DR when free B-hCG in (i) is replaced with ADAM12-S to give (v) and also reduction in DR when free B-hCG in (iii) is replaced with ADAM12-S to give (vi).