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Table 5 Modeled results

From: First trimester screening for trisomy 21 in gestational week 8-10 by ADAM12-S as a maternal serum marker

  1 in 100 1 in 250
  FPR DR FPR DR
(i) maternal age, PAPP-A & free B-hCG 4.6 77.7 9.8 87.3
(ii) maternal age, PAPP-A, free B-hCG & ADAM12-S 4.6 77.6 9.8 87.2
(iii) maternal age, PAPP-A, free B-hCG & NT 2.5 87.0 5.1 91.9
(iv) maternal age, PAPP-A, free B-hCG, NT & ADAM12-S 2.5 86.9 5.2 92.0
(v) maternal age, PAPP-A & ADAM12-S 5.4 72.3 11.9 84.3
(vi) maternal age, PAPP-A, ADAM12-S & NT 2.8 84.1 6.0 90.0
  1. Results for a screening test including maternal age, PAPP-A and ADAM12-S, with and without NT. Modeled detection rates and false-positive rates for fetal trisomy 21 at fixed risk cut-offs of 1 in 100 and 1 in 250.
  2. Increase in FPR and decrease in DR when free B-hCG in (i) is replaced with ADAM12-S to give (v) and when free B-hCG in the combined test (iii) is replaced with ADAM12-S to give (vi).