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Table 4 Detection rate for a fixed false-positive rate: Empirical results

From: First trimester screening for trisomy 21 in gestational week 8-10 by ADAM12-S as a maternal serum marker

 

DR

(95% CI)

(i) maternal age, PAPP-A & free B-hCG

76.5

(69.4, 83.7)

(ii) maternal age, PAPP-A, free B-hCG & ADAM12-S

73.7

(67.7, 79.6)

(iii) maternal age, PAPP-A, free B-hCG & NT

95.8

(94.6, 97.1)

(iv) maternal age, PAPP-A, free B-hCG, NT & ADAM12-S

92.9

(88.0, 97.8)

(v) maternal age, PAPP-A & ADAM12-S

61.6

(52.1, 71.1)

(vi) maternal age, PAPP-A, ADAM12-S & NT

83.2

(77.7, 88.8)

  1. Results for first trimester screening test with and without ADAM12-S. These results are empirical values, standardised to a reference maternal age population (UK 2000 to 2002).
  2. Detection rates for fetal trisomy 21 at a fixed false-positive rate of 5% are given. Figures in brackets are 95% confidence intervals. Reduction in DR when ADAM12-S is added to first trimester biochemistry and when ADAM12-S is added to the combined test. Substantial reduction in DR when free B-hCG in (i) is replaced with ADAM12-S to give (v) and when free B-hCG in (iii) is replaced with ADAM12-S to give (vi).
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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