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Figure 1 | Reproductive Biology and Endocrinology

Figure 1

From: Three-dimensional in vitro follicle growth: overview of culture models, biomaterials, design parameters and future directions

Figure 1

A comparison of follicular growth in a 2-D vs 3-D culture system. With 2-D growth granulosa cell migration away from the oocyte is evident with time in culture, leaving the oocyte vulnerable for premature extrusion. Pre-antral follicles embedded in hydrogel maintain their 3-D architecture. Granulosa cell expansion occurs in all directions resulting in less stress on gap junctions.

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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