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Table 1 Characteristics of included studies comparing hMG versus r-hFSH

From: Recombinant human follicle-stimulating hormone produces more oocytes with a lower total dose per cycle in assisted reproductive technologies compared with highly purified human menopausal gonadotrophin: a meta-analysis

First author, year, reference number Methods Patient population Interventions Chalmers Score
Duijkers 1997 [46] RCT, allocation method not specified Female patients with tubal pathology or unexplained infertility, ages 20 to 40 years GnRH-a for 14 days then HMG versus r-hFSH 150 IU daily 58
Jansen et al. 1998 [19] RCT, assessor-blind; allocation by number from randomization list that corresponded to medication box Normo-ovulatory females, ages 18 to 39 years; excluded endocrine-related causes, including PCOS, and male infertility HMG versus r-hFSH 150-225 IU daily for 4 days then adjusted 72
Kornilov et al. 1999 [20] RCT, allocation by randomization method not provided Female patients undergoing IVF GnRH-a long protocol then hMG versus r-hFSH 150-300 IU daily for 5 days then adjusted 67
Serhal et al. 2000 [21] Pseudo-randomised, open-label, single-centre study. Allocation by alternating weeks. Couples with infertility due to tubal factor or unexplained, endometriosis and male factor infertility allowed, female age < 40 (mean 34, SD 4.4) yrs, BMI < 30 GnRH-a long protocol then hMG versus r-hFSH 150-300 IU daily for 5 days then adjusted 60
Ng et al. 2001 [16] RCT, allocation by computerized randomization in sealed envelopes Normo-ovulatory females, age < 40 years; severe male factor requiring ICSI GnRH-a long protocol then hMG versus r-hFSH 300 IU for first 2 days, then 150 IU daily 56
Strehler et al. 2001 [22] RCT, allocation by computerized randomization Unselected female population that did not specifically exclude PCOS, age ≤ 40 years. GnRH-a short protocol then hMG versus r-hFSH 150-450 IU daily 67
Westergaard et al. 2001 [17] RCT, allocation by computerized randomization Normo-ovulatory females, age < 40 years; excluded endocrine-related causes, including PCOS GnRH-a long protocol then hMG versus r-hFSH 225 IU daily for 7 days then adjusted 64
Gordon et al. 2001 [15] RCT, assessor-blinded; allocation by computerized randomization Normo-ovulatory females, ages 20 to 39 years; excluded endocrine-related causes, including PCOS, and male infertility GnRH-a long protocol then hMG versus r-hFSH 225 IU daily for 5 days then adjusted 63
European and Israeli Study Group 2002 [14] RCT, allocation by computerized randomization list in blocks of four Normo-ovulatory females, ages 18-38 years; excluded endocrine disorders, including PCOS GnRH-a long protocol then hMG versus r-hFSH 225 IU daily for 5 days then adjusted 71
Kilani et al. 2003 [25] RCT, allocation by randomization sequence Normo-ovulatory females with no PCOS or endometriosis GnRH-a long protocol then hMG versus r-hFSH 150 IU daily for 14 days then adjusted 67
Balasch et al. 2003 [24] RCT, allocation by computerized randomization Normo-ovulatory females, ages 26-37 years with no PCOS GnRH-a long protocol then hMG versus r-hFSH 150 IU daily for 14 days then adjusted 65
Rashidi et al. 2005 [29] RCT, allocation by computerized randomization Normo-ovulatory females, ages ≤ 35 years with no PCOS or endometriosis GnRH-a long protocol then hMG versus r-hFSH 150 IU daily then adjusted 72
Andersen et al. 2006 [5] RCT, allocation by computerized randomization, stratified by patient age (< 35 years, 35-37 years) Normo-ovulatory females, ages 21-37 years; excluded PCOS, endometriosis stage III/IV, severe male factor requiring ICSI GnRH-a long protocol then hMG versus r-hFSH 225 IU daily for 5 days then adjusted 77
Hompes et al. 2008 [28] RCT, allocation by permuted blocks of random size Unselected female population, ages 18-39 years, excluding endocrine abnormality including PCOS GnRH-a long protocol then hMG versus r-hFSH 150 IU daily fixed dose with adjustment permitted 76
Bosch et al. 2008 [27] RCT, allocation by computerized allocation Normo-ovulatory females, ages 18-37 years, excluding PCOS OCP pre-treatment then hMG versus r-hFSH 225 IU daily for 2 days, then adjusted; fixed GnRH-ant protocol beginning cycle day 6 57
Ruvolo et al. 2009 [47] RCT, allocation by computerized allocation Unselected IVF female population whit FSH level of < 12 IU/mL and BMI < 28 kg/m2 GnRH-a long protocol then hMG versus r-hFSH 225 IU daily fixed dose with adjustment permitted 52
  1. RCT = randomized controlled trial; hMG = human menopausal gonadotrophins; r-hFSH = recombinant human follicle-stimulating hormone; PCOS = polycystic ovarian syndrome; GnRH-a = gonadotrophin releasing hormone agonist; IVF = in vitro fertilization; ICSI = intracytoplasmic sperm injection