From: Administration of single-dose GnRH agonist in the luteal phase in ICSI cycles: a meta-analysis
Trial | Randomization | Protocol stimulation | Luteal Phase | Results | ||
---|---|---|---|---|---|---|
Study group GnRH-a | Control group | Others medicines (all patients) | ||||
Tesarik et al., 2006 [18] | Embryo transfer day Computer generated list Opaque envelopes Blinding | GnRH-a long protocol/GnRH-ant multiple dose + r-FSH/HMG + r-HCG | n:150 GnRH-a long protocol) n:150 GnRH-ant protocol Single injection Dose:0.1 mg/triptorelin Day 6 after ICSI | n:150 (GnRHa-long protocol) n:150 (Antagonist protocol) Placebo | E2 valerate (4 mg) + Vaginal micronized progesterone(400 mg) + r-HCG (single dose) | Improvement implantation/live birth rates |
Ata et al., 2008 [24] | Embryo transfer day Computer generated list Opaque envelopes Blinding | GnRH-a long protocol + r-FSH + HCG | n:285 Single injection Dose:0.1 mg/triptorelin Day 6 after ICSI | n:285 Placebo | Vaginal progesterone gel/90 mg | No differences |
Isik et al., 2009 [15] | Embryo transfer day Computer generated list Blinding | GnRH-ant multiple dose + r-FSH/HMG + hCG/r-hCG | n:74 Single injection Dose:0.5 mg/leuprolide Day 6 after ICSI | n:80 No placebo | Vaginal micronized progesterone(600 mg) + HCG(single dose) | Improvement implantation/clinical pregnancy rates |
Razieh et al., 2009 [16] | Drawing piece of paper from a bag | GnRH-a long protocol + r-FSH + HCG | n:90 Single injection Dose:0.1 mg/triptorelin Day 5/6 after ICSI | n:90 Placebo | Vaginal micronized progesterone(800 mg) | Improvement implantation/clinical pregnancy rates |
Ata and Urman, 2010 [23] | Embryo transfer day Computer generated list Opaque envelopes Blinding | GnRH-ant multiple dose + r-FSH/HMG + r-HCG | n:38 Single injection Dose:0.1 mg/triptorelin Day 6 after ICSI | n:52 Placebo | Vaginal progesterone gel/90 mg | Lower Implantation/ongoing pregnancy rates |