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Table 1 Maternal weight and haematological parameters and litter characteristics at days 5, 10, 15 and 20 of gestation in rats fed a control or low-protein diet from mating.

From: The impact of maternal protein restriction during rat pregnancy upon renal expression of angiotensin receptors and vasopressin-related aquaporins

  Diet Gestational age (n = 7-9) Statistical significance
   5 10 15 20 GA Diet GA* Diet
Body weight (g) Control 257.3 ± 10.7d 312.8 ± 6.2c 325.3 ± 12.1b 372.8 ± 15.0a P < 0.001 NS NS
  Low protein 277.8 ± 8.2d 302.6 ± 10.7c 347.3 ± 7.4b 346.7 ± 12.8a    
Pregnancy weight gain (g) Control 26.2 ± 2.0d 63.8 ± 6.8c 82.7 ± 7.2b 137.3 ± 7.9a P < 0.05 NS NS
  Low protein 19.8 ± 3.0d 60.4 ± 6.3c 90.2 ± 5.2b 122.7 ± 13.2a    
Kidney weight (g) Control 1.04 ± 0.04b 1.10 ± 0.04 1.10 ± 0.04a 1.11 ± 0.06 P < 0.05 NS NS
  Low protein 0.88 ± 0.11b 1.11 ± 0.05 1.14 ± 0.04a 0.97 ± 0.05    
Urine volume (ml/24 hour) Control 18.3 ± 3.5 26.09 ± 4.7 22.4 ± 5.6 29.5 ± 7.4 NS NS NS
  Low protein 18.2 ± 2.9 26.6 ± 6.7 21.4 ± 3.1 20.5 ± 6.0    
Litter size (pups/litter) Control    15 ± 1 14 ± 1 NS NS NS
  Low protein    14.0 ± 1 14 ± 1    
Mean fetal weight (g) Control    0.30 ± 0.01 3.66 ± 0.11 NS NS NS
  Low protein    0.29 ± 0.01 3.37 ± 0.13    
Mean placental weight (g) Control    0.22 ± 0.01 0.51 ± 0.03 NS NS NS
  Low protein    0.22 ± 0.01 0.53 ± 0.07    
Red blood cells (106/ml) Control 6.0 ± 0.7 6.3 ± 0.7 6.6 ± 0.3 6.5 ± 0.2 NS NS NS
  Low protein 7.4 ± 0.1 6.9 ± 0.1 6.7 ± 0.2 6.3 ± 0.2    
Haemoglobin (g/dL) Control 11.3 ± 1.3 11.8 ± 1.3 12.4 ± 0.5 11.9 ± 0.4 NS NS NS
  Low protein 13.9 ± 0.2 13.0 ± 0.3 12.6 ± 0.2 11.6 ± 0.3    
Haematocrit (%) Control 30.6 ± 3.6 31.6 ± 3.6 33.3 ± 1.8 32.6 ± 1.2 NS NS NS
  Low protein 37.8 ± 0.5 35.3 ± 0.7 33.8 ± 0.5 31.3 ± 0.9    
  1. Data is presented as mean ± SEM. Data was analysed by two-way ANOVA and the statistical significance of main factor and interaction effects is shown (NS - not significant). Superscripts denote the statistical significance of post hoc analysis conducted where there was a significant effect of gestational age (superscript letters indicate a>b>c > d, P < 0.05).