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Table 3 Common pathway categories identified by GSEA of the 3 ovarian endometriosis datasets

From: A cross-study gene set enrichment analysis identifies critical pathways in endometriosis

Pathway name Classification Genes
Up-regulation   
PPAR signaling pathway Endocrine System 26
Cytokine-cytokine receptor interaction Signaling Molecules and Interaction 84
Cell adhesion molecules (CAMs) Signaling Molecules and Interaction 68
Complement and coagulation cascades Immune System 32
Toll-like receptor signaling pathway Immune System 37
Hematopoietic cell lineage Immune System 36
Asthma Immune Disorders 12
Autoimmune thyroid disease Immune Disorders 16
Systemic lupus erythematosus Immune Disorders 29
Allograft rejection Immune Disorders 16
Graft-versus-host disease Immune Disorders 17
Arachidonic acid metabolism Lipid Metabolism 19
Metabolism of xenobiotics by cytochrome P450 Xenobiotics Biodegradation and Metabolism 19
Drug metabolism - cytochrome P450 Xenobiotics Biodegradation and Metabolism 20
Type I diabetes mellitus Metabolic Disorders 19
Olfactory transduction Sensory System 4
Down-regulation   
Fatty acid metabolism Lipid Metabolism 21
Androgen and estrogen metabolism Lipid Metabolism 5
Sphingolipid metabolism Lipid Metabolism 18
Oxidative phosphorylation Energy Metabolism 44
Citrate cycle (TCA cycle) Carbohydrate Metabolism 13
Butanoate metabolism Carbohydrate Metabolism 12
Pyrimidine metabolism Nucleotide Metabolism 36
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis Glycan Biosynthesis and Metabolism 10
Lysine degradation Amino Acid Metabolism 19
Folate biosynthesis Metabolism of Cofactors and Vitamins 10
DNA polymerase Replication and Repair 22
Base excision repair Replication and Repair 16
Nucleotide excision repair Replication and Repair 19
Mismatch repair Replication and Repair 13
Homologous recombination Replication and Repair 10
Cell cycle Cell Growth and Death 57
Thyroid cancer Cancers 15
Proteasome Folding, Sorting and Degradation 13
Ubiquitin mediated proteolysis Folding, Sorting and Degradation 50
  1. Genes: Number of common genes included in the pathway.
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