Table 3 Common pathway categories identified by GSEA of the 3 ovarian endometriosis datasets
From: A cross-study gene set enrichment analysis identifies critical pathways in endometriosis
Pathway name | Classification | Genes |
|---|---|---|
Up-regulation | Â | Â |
PPAR signaling pathway | Endocrine System | 26 |
Cytokine-cytokine receptor interaction | Signaling Molecules and Interaction | 84 |
Cell adhesion molecules (CAMs) | Signaling Molecules and Interaction | 68 |
Complement and coagulation cascades | Immune System | 32 |
Toll-like receptor signaling pathway | Immune System | 37 |
Hematopoietic cell lineage | Immune System | 36 |
Asthma | Immune Disorders | 12 |
Autoimmune thyroid disease | Immune Disorders | 16 |
Systemic lupus erythematosus | Immune Disorders | 29 |
Allograft rejection | Immune Disorders | 16 |
Graft-versus-host disease | Immune Disorders | 17 |
Arachidonic acid metabolism | Lipid Metabolism | 19 |
Metabolism of xenobiotics by cytochrome P450 | Xenobiotics Biodegradation and Metabolism | 19 |
Drug metabolism - cytochrome P450 | Xenobiotics Biodegradation and Metabolism | 20 |
Type I diabetes mellitus | Metabolic Disorders | 19 |
Olfactory transduction | Sensory System | 4 |
Down-regulation | Â | Â |
Fatty acid metabolism | Lipid Metabolism | 21 |
Androgen and estrogen metabolism | Lipid Metabolism | 5 |
Sphingolipid metabolism | Lipid Metabolism | 18 |
Oxidative phosphorylation | Energy Metabolism | 44 |
Citrate cycle (TCA cycle) | Carbohydrate Metabolism | 13 |
Butanoate metabolism | Carbohydrate Metabolism | 12 |
Pyrimidine metabolism | Nucleotide Metabolism | 36 |
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | Glycan Biosynthesis and Metabolism | 10 |
Lysine degradation | Amino Acid Metabolism | 19 |
Folate biosynthesis | Metabolism of Cofactors and Vitamins | 10 |
DNA polymerase | Replication and Repair | 22 |
Base excision repair | Replication and Repair | 16 |
Nucleotide excision repair | Replication and Repair | 19 |
Mismatch repair | Replication and Repair | 13 |
Homologous recombination | Replication and Repair | 10 |
Cell cycle | Cell Growth and Death | 57 |
Thyroid cancer | Cancers | 15 |
Proteasome | Folding, Sorting and Degradation | 13 |
Ubiquitin mediated proteolysis | Folding, Sorting and Degradation | 50 |