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Figure 2 | Reproductive Biology and Endocrinology

Figure 2

From: Prolactin signaling through the short isoform of the mouse prolactin receptor regulates DNA binding of specific transcription factors, often with opposite effects in different reproductive issues

Figure 2

Transcription factors activated at both 30 and 120 min of PRL treatment in decidua and ovary of PRLR-/-RS mice. Day 9 pseudopregnant PRLR-/-RS mice were injected with ergocryptine (200 μg, sc) for 6 hr followed by a single ip injection of either PRL (60 ug) or vehicle (control). Decidua and ovaries were obtained after 0, 30 and 120 min of PRL treatment. DNA binding activities of transcription factors were measured by Protein/DNA binding assay using nuclear extracts from decidua. Upper panel, transcription factors activated by PRL in the decidua at both 30 and 120 min. Lower panel, transcription factors activated by PRL in the ovary at both 30 and 120 min.

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