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Table 8 Utility of POC and OTC urine hCG testing devises to detect hCG variants. of β-core fragment by urine POC pregnancy devices.

From: New discoveries on the biology and detection of human chorionic gonadotropin

Device

Regular hCG

Hyperglycosylated hCG

hCG Free β

Hyperglycosylated hCG free β

β-subunit core fragment

A. Point of care devices

    

Beckman Icon 25

+

?

-

-

-

Beckman Icon 20

+

?

-

-

-

Beckman Icon II

+

?

-

-

-

Inverness Acceava

+

?

?

?

-

Inverness Clearview

+

?

?

?

-

Mainline Confirms

+

?

-

-

-

Quidel Quick Vue

+

?

-

-

-

Quidel Instant Vue

+

?

-

-

-

B > Over the counter devices

    

Clear Blue Easy

+

?

+

?

-

Clear Blue Easy Digital

+

?

+

?

-

E.P.T.

+

?

+

?

-

E.P.T. Digital

+

?

+

?

-

First Response

+

-

+

+

-

First Response Digital

+

-

+

+

-

  1. Devices were tested with a sample containing 2.5 μg/L (100 IU/L) pure β-core fragment and no other form of hCG. Antigens appropriately recognized by assays (detection of standard varies from calibrated concentration by no more than 25%) are indicated by +. Those invariably detected in a specific assay (result more than 50% different from calibrated concentration) are indicated by ?, and those not detected at all are indicted by -.
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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