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Table 8 Utility of POC and OTC urine hCG testing devises to detect hCG variants. of β-core fragment by urine POC pregnancy devices.

From: New discoveries on the biology and detection of human chorionic gonadotropin

Device Regular hCG Hyperglycosylated hCG hCG Free β Hyperglycosylated hCG free β β-subunit core fragment
A. Point of care devices     
Beckman Icon 25 + ? - - -
Beckman Icon 20 + ? - - -
Beckman Icon II + ? - - -
Inverness Acceava + ? ? ? -
Inverness Clearview + ? ? ? -
Mainline Confirms + ? - - -
Quidel Quick Vue + ? - - -
Quidel Instant Vue + ? - - -
B > Over the counter devices     
Clear Blue Easy + ? + ? -
Clear Blue Easy Digital + ? + ? -
E.P.T. + ? + ? -
E.P.T. Digital + ? + ? -
First Response + - + + -
First Response Digital + - + + -
  1. Devices were tested with a sample containing 2.5 μg/L (100 IU/L) pure β-core fragment and no other form of hCG. Antigens appropriately recognized by assays (detection of standard varies from calibrated concentration by no more than 25%) are indicated by +. Those invariably detected in a specific assay (result more than 50% different from calibrated concentration) are indicated by ?, and those not detected at all are indicted by -.