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Table 7 Ability of automated laboratory immunometric hCG tests to detect hCG variants in 30 serum samples from gestational trophoblastic disease and cancer patients.

From: New discoveries on the biology and detection of human chorionic gonadotropin

Diagnosis Abbott AxSym hCGβ mIU/ml (% median) Baxter Stratus hCG mIU/ml (% median) Siemens ACS180 hCG mIU/ml (% median) Beckman Access hCGβ mIU/ml (% median) Siemens Immulite hCG mIU/ml (% median)
Partial mole 5 (112%) 2 (53%) 3 (72%) 6 (127%) 4 (88%)
Choriocarcinoma 7 (110%) 3 (49%) 5 (71%) 9 (133%) 6 (90%)
Partial mole 10 (107%) 7 (73%) 7 (70%) 10 (108%) 9 (93%)
Complete mole 16 (117%) 12 (89%) 14 (104%) 15 (115%) 13 (96%)
Complete mole 18 (132%) 6 (42%) 14 (104%) 18 (131%) 11 (84%)
Complete mole 16 (119%) 7 (53%) 11 (81%) 16 (119%) 11 (80%)
Partial mole 26 (110%) 15 (62%) 22 (95%) 25 (105%) 19 (81%)
Complete mole 40 (133%) 15 (51%) 30 (100%) 36 (119%) 29 (96%)
Ovarian dysgerminoma 85 (138%) 34 (55%) 63 (102%) 72 (118%) 47 (76%)
Complete mole 91 (116%) 56 (71%) 88 (112%) 90 (114%) 69 (88%)
Testicular germ cell 102 (124%) 60 (73%) 88 (107%) 92 (112%) 78 (95%)
Partial mole 88 (104%) 59 (70%) 81 (96%) 91 (108%) 81 (96%)
Choriocarcinoma 126 (126%) 78 (78%) 102 (102%) 128 (128%) 101 (101%)
Partial mole 153 (143%) 69 (64%) 103 (97%) 121 (114%) 110 (103%)
Serous Ovarian Cancer 70 (64%) 1 (0.9%) 65 (59%) 67 (61%) 115 (105%)
Complete mole 198 (130%) 106 (70%) 159 (104%) 176 (116%) 146 (96%)
Partial mole 245 (124%) 138 (70%) 188 (95%) 214 (109%) 206 (105%)
Ovarian dysgerminoma 221 (99%) 64 (29%) 226 (101%) 242 (108%) 184 (82%)
Partial mole 291 (127%) 173 (75%) 260 (113%) 256 (111%) 224 (97%)
Partial mole 48 (20%) 9 (3.8%) 31 (13%) 15 (6.3%) 235 (99%)
Complete mole 607 (108%) 453 (81%) 603 (108%) 614 (110%) 560 (100%)
Partial mole 668 (115%) 475 (82%) 725 (124%) 782 (134%) 555 (95%)
Choriocarcinoma 603 (93%) 687 (107%) 955 (148%) 842 (131%) 550 (85%)
Complete mole 717 (94%) 759 (99%) 999 (131%) 924 (121%) 769 (101%)
Complete mole 704 (91%) 666 (86%) 943 (122%) 925 (97%) 751 (119%)
Complete mole 1,109 (131%) 655 (77%) 904 (107%) 972 (115%) 827 (98%)
Partial mole 1,027 (112%) 891 (98%) 1,230 (135%) 1,094 (120%) 930 (102%)
Complete mole 9576 (69%) 7995 (58%) 6378 (46%) 7437 (54%) 16320 (118%)
Complete mole 21515 (42%) 16305 (32%) 17070 (33%) 19005 (37%) 52350 (102%)
Choriocarcinoma 13640 (102%) 12145 (91%) 12970 (97%) 13310 (100%) 14720 (111%)
Varies by > 25% median 11 of 30 results 21 of 30 results 10 of 30 results 10 of 30 results 0 results
  1. Blindly determined results are presented, as are percents variation of the median result. The proportion of samples using each tests that varies by > 25% of median results is determined.
  2. a hCG missing βCTP, median determined with assays detecting βCTP (Siemens Immulite, Siemens Dimension and hCGβ radioimmoassay)