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Table 2 Detection of total hCG, hyperglycosylated hCG and hyperglycosylated hCG free β in pregnancy serum [43, 45–48].

From: New discoveries on the biology and detection of human chorionic gonadotropin

Gestation age (weeks since last menses)

N

Total hCG

Median (mIU/ml)

Hyperglycosylated hCG

(%) mean ± SD

Hyperglycosylated hCG free β (%) mean ± SD

3 weeks (implantation)

n = 5

22

89 ± 24%

12 ± 22%

4 weeks (missing menses)

n = 16

239

49 ± 21%

7.3 ± 5.9%

5 weeks

n = 27

3,683

36 ± 13%

1.7 ± 0.75%

6 weeks

n = 25

16,850

21 ± 14%

1.4 ± 0.63%

7 weeks

n = 22

32,095

16 ± 13%

1.0 ± 0.24%

8 weeks

n = 33

95,282

7.0 ± 5.4%

0.99 ± 0.51%

9 weeks

n = 7

128,300

5.1 ± 4.4%

0.92 ± 0.35%

10 weeks

n = 8

102,750

4.3 ± 3.1%

0.68 ± 0.47%

11 – 13 weeks

n = 21

95,650

2.3 ± 1.5%

0.67 ± 0.33%

14 – 17 weeks

n = 57

32,275

1.3 ± 0.61%

0.62 ± 0.26%

18 – 26 weeks

n = 62

21,250

0.65 ± 0.60%

0.55 ± 0.42%

27 – 40 weeks

n = 49

21,025

0.36 ± 0.16%

0.47 ± 0.19%

  1. Proportion hyperglycosylated hCG and hyperglycosylated hCG free β is the concentrations measured as a proportion of total hCG. SD is standard deviation. Gestational age is 3 day plus and 3 days minus specified week. So that data for 6 weeks pregnancy is 5 weeks 4 days to 6 weeks 3 days.