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Figure 5 | Reproductive Biology and Endocrinology

Figure 5

From: MyD88 and TRIF mediate the cyclic adenosine monophosphate (cAMP) induced corticotropin releasing hormone (CRH) expression in JEG3 choriocarcinoma cell line

Figure 5

Proposed Mechanism of MyD88 Regulation of cAMP signalling. MyD88 interacts with TIRAP and PIP2 in the plasma membrane and associates with AKAP. AKAPs are known to regulate cAMP signaling through PKA. MyD88 may regulate cAMP signaling in a complex involving TIRAP-PIP2-AKAP. [ATP- Adenosine-5'-triphosphate; AC-adenylate cyclase; PIP2-phosphatidylinositol 4,5-bisphosphate; AKAP-A-kinase anchoring proteins; PKA-protein kinase A; CRE-cAMP-response element; TIRAP-TIR domain containing adaptor molecule; CREB-P-phosphorylated cAMP-response element binding (CREB)]

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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