Figure 4
From: Molecular and functional characterization of voltage-gated sodium channels in human sperm
Effects of veratridine on human sperm motility. (A) Dose-response effects of veratridine (10-7 M-10-5 M) after 15 min incubation. Data represent percentage changes in sperm A + B, C and D motility grades between samples treated with veratridine and its solvent (paired controls). aP < 0.05 versus responses in solvent-treated controls. bP < 0.05 versus responses to veratridine 10-7 M; cP < 0.05 versus responses to veratridine 10-6 M, one-way ANOVA. (B) Time-course of the effects of veratridine (3 × 10-6 M) after 2, 15, 30 and 60 min incubation. Data represent percentage changes in sperm A, B, C and D motility grades between samples treated with veratridine and its solvent (paired controls). aP < 0.05 versus responses at time 0; bP < 0.05 versus responses at time 2, cP < 0.05 versus responses at time 15, one-way ANOVA. Each bar is the mean with SEM of 6–12 different experiments.