Table 2 Methadone concentration measured in the initial maternal medium (M0) and after two hours of perfusion in the maternal medium (ME), the fetal medium (FE) and in the perfused tissue (TE)
From: The impact of cocaine and heroin on the placental transfer of methadone
ME [ng/ml] (% Recovery) | FE [ng/ml] (% Recovery) | TE [ng/g] (% Recovery) | Cotyledon Weight [g] | |
|---|---|---|---|---|
Perfusion with methadone (n = 6) | <0.69 (0) | <0.69 (0) | 1987 ± 587 (94) | 20.1 ± 3.4 |
Perfusion with methadone plus cocaine (n = 6) | 1.6 ± 1.1 (0.6) | <0.69 (0) | 2814 ± 352 (96) | 19.6 ± 2.3 |
Perfusion with methadone plus heroin (n = 6) | 57 ± 22 (6) | 8 ± 10 (1) | 3427 ± 374a(92) | 20.3 ± 2.7 |