Figure 4From: The impact of cocaine and heroin on the placental transfer of methadoneA. Western blot analysis of P-glycoprotein expression in the isolated brush border membrane before perfusion (T0) and after perfusion (TE). CTR: control; +MTD: methadone; +MTD+COC: methadone plus cocaine; +MTD+HRO: methadone plus heroin. B. P-glycoprotein expression (percentage of actin) in the isolated brush border membrane after perfusion with methadone (TE+MTD), methadone plus cocaine (TE+MTD+COC) and methadone plus heroin (TE+MTD+HRO). Values are expressed as mean ± SD (n = 6) of the percentage of the control (tissue before perfusion: T0-CTR = 100%). *P = 0.03 vs. T0-CTR, **P = 0.01 vs. T0-CTR, ***P = 0.03 vs. T0-CTR.Back to article page