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Table 1 r-hFSH and r-hLH mixing scheme*

From: Administration of follitropin alfa and lutropin alfa combined in a single injection: a feasibility assessment

  

Follitropin alfa/lutropin alfa 150 IU/75 IU

Follitropin alfa 75 IU

Follitropin alfa 900 IU

r-hFSH:r-hLH ratio

Ratio Group 1

FSH

150 IU

75 IU in 1 mL

--

3:1

 

LH

75 IU

--

--

 

Ratio Group 2

FSH

150 IU

--

75 IU in 0.125 mL

3:1

 

LH

75 IU

--

--

 

Ratio Group 3

FSH

150 IU

225 IU in 1 mL

--

5:1

 

LH

75 IU

--

--

 

Ratio Group 4

FSH

150 IU

--

450 IU in 0.75 mL

8:1

 

LH

75 IU

--

--

 
  1. r-hFSH, recombinant human follicle-stimulating hormone; r-hLH, recombinant human luteinizing hormone.
  2. *Follitropin alfa was reconstituted with water for injection and then added to follitropin alfa/lutropin alfa lyophilized powder. The final reconstituted volume was always approximately 1 mL.