Figure 1
From: The estrogen-injected female mouse: new insight into the etiology of PCOS
Creation of follicular cysts in Tx-3 female mice by the infusion of lymphocytes from E 2 - and DES-injected female B6A mice. Cross-section of ovary from a 100-day-old mouse (A), given sc injections of 10 μl sesame oil:ethanol (9:1; v:v) [vehicle] at 5–7 days of age. Cross-section of ovary from the 100-day-old recipient Tx-3 mouse (B), infused at 15 days of age with 20 million lymphocytes, taken from the vehicle-injected animal. Cross-section of ovary from a 100-day-old mouse (C), given injections of 20 μg E2 in 10 μl vehicle at 5–7 days of age. Cross-section of ovary from the 100-day-old recipient Tx-3 mouse (D), infused at 15 days of age with 20 million lymphocytes, taken from the E2-injected animal. Cross-section of ovary from a 100-day-old mouse (E), given injections of 10 μg DES in 10 μl vehicle at 5–7 days of age. Cross-section of ovary from the 100-day-old recipient Tx-3 mouse (F), infused at 15 days of age with 20 million lymphocytes, taken from the DES-injected animal.