Top canonical pathways affected by. A. Up-regulated genes after NASP overexpression. B. Down-regulated genes after NASP overexpression. C. Up-regulated genes after NASP depletion. D. Down-regulated genes after NASP depletion. Bars represent -log (p-value) for disproportionate representation of affected genes in the selected pathway, yellow line represents the ratio of affected genes to the total number of genes in a pathway. Threshold (red line) denotes the p = 0.05 level.