Figure 3From: Mechanisms of matrix metalloproteinase-2 (mmp-2) transcriptional repression by progesterone in jar choriocarcinoma cellsMMP-2 luciferase reporter activities: effects of progesterone. (A) JAR cells transfected with control pGL2 vector or pGL2 vector containing the human MMP-2 promoter in the presence or absence of progesterone (1 μM–10 μM) or in combination with RU486 (MI, 10–6 M). (B) JAR cells transfected with pGL2 containing the full length (1686 bp) human or rat promoters in the absence or presence of progesterone (1 μM). Results represent mean ± SEM from four independent experiments; * P < 0.05. Black bars: human MMP-2 promoter; white bars: rat MMP-2 promoter.Back to article page