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Table 5 Genes > 2 fold up- or down-regulated after hormone treatment in HEC1A and/or RL95-2 cell line

From: Genes targeted by the estrogen and progesterone receptors in the human endometrial cell lines HEC1A and RL95-2

Up-regulation > 2 fold   ChIP target post E2 treatment   ChIP target post P4 treatment
HEC1A Molecular function* E2   P4  
MEF2D Other transcription factor; Nucleic acid binding 6 h HEC1A ERβ 3 h RL95-2 PRB
RL95-2   E2   P4  
CD86 Immunoglobulin receptor family member; Membrane-bound signaling molecule; Defense/immunity protein 3 h HEC1A ERα NS ND
MEF2D Other transcription factor; Nucleic acid binding 3 h HEC1A ERβ 3 h RL95-2 PRB
OTOF Otoferlin 12 h HEC1A ERα and ERβ 3 h HEC1A PRA
PLXNA2 Tyrosine protein kinase receptor;Protein kinase 3 h RL95-2 ERβ 3 h RL95-2 PRA
RELB Other transcription factor 3 h HEC1A ERα NS ND
SMARCA2 DNA helicase 3 h RL95-2 ERα 3 h ND
TNC Cell adhesion molecule; Extracellular matrix glycoprotein 3 h HEC1A ERβ 3 h RL95-2 PRA
Down-regulation > 2 fold     
HEC1A Molecular function* E2   P4  
CD86 Immunoglobulin receptor family member; Membrane-bound signaling molecule; Defense/immunity protein 6 h HEC1A ERα NS ND
FOXA2 Other transcription factor; Nucleic acid binding 3 h RL95-2 ERβ 12 h ND
MMP7 Metalloprotease; Other extracellular matrix 12 h HEC1A ERα and ERβ 12 h ND
NCOA1 Transcription factor; Acetyltransferα se 3 h ND 6 h RL95-2 PRA
RELB Other transcription factor 3 h HEC1A ERα 6 h ND
TNC Cell adhesion molecule; Extracellular matrix glycoprotein 3 h HEC1A ERβ 6 h RL95-2 PRA
ZNF549 KRAB box transcription factor   HEC1A ERα and ERβ 6 h RL95-2 PRA
RL95-2   E2   P4  
CD86 Immunoglobulin receptor family member; Membrane-bound signaling molecule; Defense/immunity protein 12 h HEC1A ERα NS ND
IHH Other signaling molecule; Protease 12 h HEC1A ERα/ERβ 6 h RL95-2 PRB
  1. (*) Molecular functions were obtained from PANTHER. In bold are genes with cell line-specific expression. NS: not significant gene expression, ND: not detected. Official gene symbols according to HUGO Gene Nomenclature Committee (HGNC).