Table 5 Genes > 2 fold up- or down-regulated after hormone treatment in HEC1A and/or RL95-2 cell line
Up-regulation > 2 fold | ChIP target post E2 treatment | ChIP target post P4 treatment | |||
|---|---|---|---|---|---|
HEC1A | Molecular function* | E2 | P4 | ||
MEF2D | Other transcription factor; Nucleic acid binding | 6 h | HEC1A ERβ | 3 h | RL95-2 PRB |
RL95-2 | E2 | P4 | |||
CD86 | Immunoglobulin receptor family member; Membrane-bound signaling molecule; Defense/immunity protein | 3 h | HEC1A ERα | NS | ND |
MEF2D | Other transcription factor; Nucleic acid binding | 3 h | HEC1A ERβ | 3 h | RL95-2 PRB |
OTOF | Otoferlin | 12 h | HEC1A ERα and ERβ | 3 h | HEC1A PRA |
PLXNA2 | Tyrosine protein kinase receptor;Protein kinase | 3 h | RL95-2 ERβ | 3 h | RL95-2 PRA |
RELB | Other transcription factor | 3 h | HEC1A ERα | NS | ND |
SMARCA2 | DNA helicase | 3 h | RL95-2 ERα | 3 h | ND |
TNC | Cell adhesion molecule; Extracellular matrix glycoprotein | 3 h | HEC1A ERβ | 3 h | RL95-2 PRA |
Down-regulation > 2 fold | |||||
HEC1A | Molecular function* | E2 | P4 | ||
CD86 | Immunoglobulin receptor family member; Membrane-bound signaling molecule; Defense/immunity protein | 6 h | HEC1A ERα | NS | ND |
FOXA2 | Other transcription factor; Nucleic acid binding | 3 h | RL95-2 ERβ | 12 h | ND |
MMP7 | Metalloprotease; Other extracellular matrix | 12 h | HEC1A ERα and ERβ | 12 h | ND |
NCOA1 | Transcription factor; Acetyltransferα se | 3 h | ND | 6 h | RL95-2 PRA |
RELB | Other transcription factor | 3 h | HEC1A ERα | 6 h | ND |
TNC | Cell adhesion molecule; Extracellular matrix glycoprotein | 3 h | HEC1A ERβ | 6 h | RL95-2 PRA |
ZNF549 | KRAB box transcription factor | HEC1A ERα and ERβ | 6 h | RL95-2 PRA | |
RL95-2 | E2 | P4 | |||
CD86 | Immunoglobulin receptor family member; Membrane-bound signaling molecule; Defense/immunity protein | 12 h | HEC1A ERα | NS | ND |
IHH | Other signaling molecule; Protease | 12 h | HEC1A ERα/ERβ | 6 h | RL95-2 PRB |