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Figure 1 | Reproductive Biology and Endocrinology

Figure 1

From: Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes

Figure 1

Structural domains of PARP and its fragments showing. A: DNA binding domain containing Zinc fingers (F1-F3) for nucleosome binding and nuclear localization (NLS) segment; Automodification domain responsible for adding ADPR (ADP ribose) polymers through binding with Lysine (K) amino acid and catalytic domain has the PARP signature and PARP enzymatic activity. B: Full length PARP1 113 KDa molecule with a mark on the site of cleavage (214/215 amino acids) C: PARP cleavage by caspase showing short (24 KDa) and long (89 KDa) cleaved PARP fragments.

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