Figure 6

Proposed hypothesis of epithelial endometrial receptors role in endometrial receptivity and attachment stage. (A) Different expression pattern of endometrial receptors (PR, c-MET, PB1) in endometrial cells at the window of implantation and in endometrial cells before the window of implantation. (B) Attachment stage is mediated by epithelial endometrial receptors: PRA, hetrodimer of PB1 – c-MET (mainly 140 kDa form) and homodimer of PB1 (C) Signal transduction is activated in the embryo and endometrial cells. (D) Interaction of trophoblast embryo cells with epithelial endometrial cells leading to attachment and to implantation.