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Table 3 Endogenous occurrence of D-aspartate in rat tissues and accumulation after treatment with sodium D-aspartate

From: The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats

  Basal levels of D-Asp Levels of D-Asp after 12 days of D-Asp treatment Levels of D-Asp 3 days after the suspension of D-Asp treatment
Pituitary 129 ± 12 880 ± 45* 145 ± 12
Testes 109 ± 8 780 ± 45* 205 ± 14*
Thyroid 90 ± 6 350 ± 19* 110 ± 9
Hippocampus 62 ± 5 108 ± 9* 78 ± 7
Frontal cortex 41 ± 4 85 ± 7* 55 ± 5
Liver 12 ± 3 24 ± 2* 11 ± 3
Kidney 10 ± 2 45 ± 4* 13 ± 3
Serum 4 ± 1 8 ± 2* 3 ± 1
  1. A group of 10 male rats (120-130 days old) rats were allowed to drink 20 mM sodium D-aspartate for 12 days. A second group of 10 male rats of the same age were allowed to drink 20 mM sodium D-aspartate for 12 days and then drink tap water for 3 days. A third group of 10 rats male rats of the same age drank 20 mM of NaCl for 12 days (placebo). All rat were sacrificed and collected serum and solid tissues and determined the concentration of D-Asp. Values are the mean ± SEM. Asterisks indicated that the difference between treated animals and control were statistically significant for a p < 0.001 evaluated by one-way ANOVA.