The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats

Table 1 Effects of D-aspartate on LH and testosterone release in human serum

	Basal levels treatment	After 6 days of D-Asp treatment	After 12 days of D-Asp	3 days after the suspension of D-Asp
	LH (mIU/ml serum)
Subjects treated with with Na-D-aspartate	4.2 ± 0.5	4.5 ± 0.6	5.6 ± 0.9*	4.8 ± 0.8
Subjects treated with placebo	4.2 ± 0.4	4.3 ± 0.7	4.2 ± 0.6	4.1 ± 0.5
	Testosterone (ng/ml serum)
Subjects treated with Na-D-aspartate	4.5 ± 0.6	5.2 ± 0.7	6.4 ± 0.8*	5.8 ± 0.6*
Subjects treated with placebo	4.6 ± 0.5	4.5 ± 0.7	4.7 ± 0.7	4.6 ± 0.7

These results are the mean ± SEM of LH and testosterone in serum of 23 participants (aged 27-37 years) at zero time (basal levels), after 6 days and 12 days of D-aspartate treatment and 3 days after the suspension of treatment. Subjects drank a daily dose of DADAVIT^® (Na-D-aspartate). The placebo treatment was carried out on another 20 participants of the same age, who drank a daily dose of DADAVIT^® placebo. Statistical analysis was conducted using ANOVA with repeated measures (post-hoc test). * Values are statistically significant for p < 0.001.