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Table 5 Clinical and laboratory outcomes of COH in ICSI cycles with clinical pregnancy during the 865 cycles.

From: A comparison of menotropin, highly-purified menotropin and follitropin alfa in cycles of intracytoplasmic sperm injection

  hMG
(n = 106)
HP-hMG
(n = 132)
r-hFSH
(n = 82)
p value
Mean age, years (± SD) 31.1 (± 5.0)a 32.7 (± 4.2)b 32.8 (± 4.2)c 0.01
(a vs b, c)
   ≤35 years (± SD) 29.2 (± 3.6)a 30.7 (± 3.1)b 30.8 (± 2.9)c 0.004
(a vs b, c)
   >35 years (± SD) 38.3 (± 1.9)a 37.0 (± 2.0)b 37.3 (± 1.6)c 0.04
(a vs b, c)
Mean length of stimulation, days (± SD) 9.6 (± 1.3)a 9.8 (± 1.0)b 10.0 (± 1.0)c 0.01
(a vs b, c)
   ≤35 years 9.5 (± 1.3)a 9.9 (± 1.0)b 10.0 (± 0.9)c 0.001
(a vs b, c)
   >35 years 10.1 (± 1.3)a 9.7 (± 1.0)b 9.9 (± 1.0)c 0.66
Mean baseline FSH, IU/L (± SD) 6.0 (± 2.4) 6.5 (± 3.7) 6.3 (± 2.2) 0.63
   ≤35 years 5.8 (± 2.2) 6.2 (± 2.9) 6.0 (± 2.0) 0.51
   >35 years 6.6 (± 3.2) 7.1 (± 5.0) 7.1 (± 4.5) 0.91
Mean baseline LH, IU/L (± SD) 5.6 (± 5.3) 5.5 (± 3.7) 5.2 (± 3.0) 0.90
   ≤35 years 5.7 (± 5.6) 5.5 (± 4.0) 5.3 (± 4.1) 0.89
   >35 years 5.2 (± 3.5) 5.4 (± 2.7) 5.5 (± 3.1) 0.70
Mean estradiol on day of hCG, pg/mL (± SD) 2102.8
(± 1207.4)a
2682.9
(± 1440.7)b
2488.0 (± 1630.7)c 0.005
(a vs b)
   ≤35 years 2225.5
(± 1221.0)a
2753.3
(± 1402.3)b
2742.9
(± 1716.8)c
0.01
(a vs b, c)
   >35 years 1605.7
(± 1036.6)
2510.7
(± 1537.5)
1850.9
(± 1203.6)
0.06
Mean number of retrieved oocytes, n (± SD) 12.1 (± 6.6) 12.2 (± 6.1) 12.4 (± 6.8) 0.92
   ≤35 years 13.0 (± 6.7) 12.4 (± 5.2) 12.3 (± 5.9) 0.92
   >35 years 8.7 (± 5.1) 11.5 (± 8.0) 12.5 (± 9.0) 0.25
Mean MII oocytes, n (± SD) 9.7 (± 4.8) 10.3 (± 5.5) 9.9 (± 5.5) 0.67
   ≤35 years 10.6 (± 4.8) 10.3 (± 4.6) 9.7 (± 4.6) 0.20
   >35 years 6.4 (± 3.1) 10.1 (± 7.3) 10.6 (± 7.3) 0.05
Fertilization rate 2PN, % (± SD) 77 (± 17) 76 (± 17) 75 (± 18) 0.71
   ≤35 years 74 (± 17) 74 (± 17) 75 (± 17) 0.91
   >35 years 88 (± 12) 79 (± 18) 76 (± 19) 0.07
Top quality embryos on day3, % (± SD) 47 (± 28)a 55 (± 28)b 41 (± 25)c 0.004
(b vs a, c)
   ≤35 years 49 (± 26)a 54(± 28)b 40 (± 26)c 0.02
(b vs c)
   >35 years 40 (± 32)a 60 (± 29)b 44 (± 22)c 0.02
(b vs a, c)
Mean number of transferred embryos, n (± SD) 3.9 (± 1.0) 3.8 (± 0.9) 3.6 (± 0.9) 0.65
   ≤35 years 3.4 (± 1.0) 3.6 (± 0.9) 3.5 (± 0.9) 0.79
   >35 years 4.0 (± 0.9) 4.0 (± 0.8) 3.9 (± 0.9) 0.33
  1. Distribution by menotropin (hMG), highly-purified menotropin (HP-hMG) or follitropin alfa (r-hFSH) for COH. Overall and age-stratified outcomes are presented.
  2. 2PN, two pronuclei; COH, controlled ovarian hyperstimulation; FSH, follicle-stimulating hormone; hCG, human chorionic gonadotropin; hMG, human menopausal gonadotropin; HP-hMG, highly-purified hMG; ICSI, intracytoplasmic sperm injection; LH, luteinizing hormone; MII, metaphase II; r-hFSH, recombinant human FSH; SD, standard deviation.