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Table 5 Clinical and laboratory outcomes of COH in ICSI cycles with clinical pregnancy during the 865 cycles.

From: A comparison of menotropin, highly-purified menotropin and follitropin alfa in cycles of intracytoplasmic sperm injection

 

hMG

(n = 106)

HP-hMG

(n = 132)

r-hFSH

(n = 82)

p value

Mean age, years (± SD)

31.1 (± 5.0)a

32.7 (± 4.2)b

32.8 (± 4.2)c

0.01

(a vs b, c)

   ≤35 years (± SD)

29.2 (± 3.6)a

30.7 (± 3.1)b

30.8 (± 2.9)c

0.004

(a vs b, c)

   >35 years (± SD)

38.3 (± 1.9)a

37.0 (± 2.0)b

37.3 (± 1.6)c

0.04

(a vs b, c)

Mean length of stimulation, days (± SD)

9.6 (± 1.3)a

9.8 (± 1.0)b

10.0 (± 1.0)c

0.01

(a vs b, c)

   ≤35 years

9.5 (± 1.3)a

9.9 (± 1.0)b

10.0 (± 0.9)c

0.001

(a vs b, c)

   >35 years

10.1 (± 1.3)a

9.7 (± 1.0)b

9.9 (± 1.0)c

0.66

Mean baseline FSH, IU/L (± SD)

6.0 (± 2.4)

6.5 (± 3.7)

6.3 (± 2.2)

0.63

   ≤35 years

5.8 (± 2.2)

6.2 (± 2.9)

6.0 (± 2.0)

0.51

   >35 years

6.6 (± 3.2)

7.1 (± 5.0)

7.1 (± 4.5)

0.91

Mean baseline LH, IU/L (± SD)

5.6 (± 5.3)

5.5 (± 3.7)

5.2 (± 3.0)

0.90

   ≤35 years

5.7 (± 5.6)

5.5 (± 4.0)

5.3 (± 4.1)

0.89

   >35 years

5.2 (± 3.5)

5.4 (± 2.7)

5.5 (± 3.1)

0.70

Mean estradiol on day of hCG, pg/mL (± SD)

2102.8

(± 1207.4)a

2682.9

(± 1440.7)b

2488.0 (± 1630.7)c

0.005

(a vs b)

   ≤35 years

2225.5

(± 1221.0)a

2753.3

(± 1402.3)b

2742.9

(± 1716.8)c

0.01

(a vs b, c)

   >35 years

1605.7

(± 1036.6)

2510.7

(± 1537.5)

1850.9

(± 1203.6)

0.06

Mean number of retrieved oocytes, n (± SD)

12.1 (± 6.6)

12.2 (± 6.1)

12.4 (± 6.8)

0.92

   ≤35 years

13.0 (± 6.7)

12.4 (± 5.2)

12.3 (± 5.9)

0.92

   >35 years

8.7 (± 5.1)

11.5 (± 8.0)

12.5 (± 9.0)

0.25

Mean MII oocytes, n (± SD)

9.7 (± 4.8)

10.3 (± 5.5)

9.9 (± 5.5)

0.67

   ≤35 years

10.6 (± 4.8)

10.3 (± 4.6)

9.7 (± 4.6)

0.20

   >35 years

6.4 (± 3.1)

10.1 (± 7.3)

10.6 (± 7.3)

0.05

Fertilization rate 2PN, % (± SD)

77 (± 17)

76 (± 17)

75 (± 18)

0.71

   ≤35 years

74 (± 17)

74 (± 17)

75 (± 17)

0.91

   >35 years

88 (± 12)

79 (± 18)

76 (± 19)

0.07

Top quality embryos on day3, % (± SD)

47 (± 28)a

55 (± 28)b

41 (± 25)c

0.004

(b vs a, c)

   ≤35 years

49 (± 26)a

54(± 28)b

40 (± 26)c

0.02

(b vs c)

   >35 years

40 (± 32)a

60 (± 29)b

44 (± 22)c

0.02

(b vs a, c)

Mean number of transferred embryos, n (± SD)

3.9 (± 1.0)

3.8 (± 0.9)

3.6 (± 0.9)

0.65

   ≤35 years

3.4 (± 1.0)

3.6 (± 0.9)

3.5 (± 0.9)

0.79

   >35 years

4.0 (± 0.9)

4.0 (± 0.8)

3.9 (± 0.9)

0.33

  1. Distribution by menotropin (hMG), highly-purified menotropin (HP-hMG) or follitropin alfa (r-hFSH) for COH. Overall and age-stratified outcomes are presented.
  2. 2PN, two pronuclei; COH, controlled ovarian hyperstimulation; FSH, follicle-stimulating hormone; hCG, human chorionic gonadotropin; hMG, human menopausal gonadotropin; HP-hMG, highly-purified hMG; ICSI, intracytoplasmic sperm injection; LH, luteinizing hormone; MII, metaphase II; r-hFSH, recombinant human FSH; SD, standard deviation.