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Table 3 Clinical and laboratory outcomes of COH during the 865 ICSI cycles.

From: A comparison of menotropin, highly-purified menotropin and follitropin alfa in cycles of intracytoplasmic sperm injection

  hMG
(n = 299)
HP-hMG
(n = 330)
r-hFSH
(n = 236)
p value
Mean length of stimulation, days (± SD) 9.6 (± 1.3)a 10.0 (± 1.3)b 10.1 (± 1.0)c < 0.001
(a vs b, c)
   ≤35 years 9.5 (± 1.3)a 9.9 (± 1.2)b 10.0 (± 0.9)c < 0.001
(a vs b, c)
   >35 years 9.8 (± 1.4)a 10.2 (± 1.6)b 10.2 (± 1.1)c 0.007
(a vs b, c)
Gonadotropin dose adjustment, n (%) 56 (18.7)a 67 (20.3)b 126 (53.4)c < 0.001
(c vs a, b)
   ≤35 years 43 (20.1)a 47 (23.7)b 90 (63.3)c < 0.001
(c vs a, b)
   >35 years 13 (15.1)a 20 (15.1)b 36 (38.2)c < 0.001
(c vs a, b)
Mean estradiol on day of hCG, pg/mL (± SD) 1967.0
(± 1241.0)a
2479.0
(± 1708.0)b
2159.3 (± 1411.7)c 0.001
(a vs b, c)
   ≤35 years 2174.8
(± 1224.4)a
2609.3
(± 1632.0)b
2392.3
(± 1422.3)c
0.035
(a vs b)
   >35 years 1432.7
(± 1124.6)a
2285.1
(± 1804.4)b
1789.1
(± 1325.7)c
0.001
(a vs b)
Cancellation rate, n (%) 23 (7.7) 21 (6.4) 17 (7.2) 0.80
   ≤35 years 10 (4.7) 9 (4.5) 10 (7.0) 0.50
   >35 years 13 (15.1) 12 (9.0) 7 (7.4) 0.20
Severe OHSS, n (%) 7 (2.3) 6 (1.8) 3 (1.3) 0.76
   ≤35 years, n 5 4 3 -
   >35 years, n 2 2 0 -
Mean number of retrieved oocytes, n (± SD) 10.9 (± 6.8) 10.7 (± 6.5) 10.8 (± 6.7) 0.97
   ≤35 years 12.3 (± 6.7) 11.3 (± 5.5) 11.7 (± 6.0) 0.50
   >35 years 7.5 (± 5.8) 9.7 (± 7.6) 9.5 (± 7.5) 0.08
Mean MII oocytes, n (± SD) 8.9 (± 5.6) 8.9 (± 5.7) 8.7 (± 5.6) 0.82
   ≤35 years 10.1 (± 5.5) 9.4 (± 4.8) 9.1 (± 5.0) 0.20
   >35 years 5.8 (± 4.4)a 8.3 (± 6.8)b 8.1 (± 6.3)c 0.01
(a vs b, c)
Fertilization rate 2PN, % (± SD) 72 (± 25) 72 (± 22) 71 (± 23) 0.83
   ≤35 years 71 (± 22) 72 (± 22) 72 (± 22) 0.76
   >35 years 73 (± 30) 72 (± 24) 70 (± 25) 0.20
Top quality embryos on day3, % (± SD) 40 (± 30)a 47 (± 31)b 39 (± 29)c 0.004
(b vs a, c)
   ≤35 years 41 (± 29)a 47 (± 28)b 39 (± 28)c 0.03
(b vs a, c)
   >35 years 39 (± 34) 48 (± 34) 37 (± 30) 0.08
Mean number of transferred embryos, n (± SD) 3.4 (± 1.6) 3.4 (± 1.5) 3.2 (± 1.6) 0.18
   ≤35 years 3.5 (± 1.4) 3.5 (± 1.4) 3.2 (± 1.4) 0.05
   >35 years 2.9 (± 1.9) 3.1 (± 1.6) 3.2 (± 1.8) 0.50
  1. Distribution by menotropin (hMG), highly-purified menotropin (HP-hMG) or follitropin alfa (r-hFSH) for COH. Overall and age-stratified outcomes are presented.
  2. 2PN, two pronuclei; COH, controlled ovarian hyperstimulation; human chorionic gonadotropin; hMG, human menopausal gonadotropin; HP-hMG, highly-purified hMG; ICSI, intracytoplasmic sperm injection; MII, metaphase II; OHSS, ovarian hyperstimulation syndrome; r-hFSH, recombinant human follicle-stimulating hormone; SD, standard deviation.