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Table 3 Clinical and laboratory outcomes of COH during the 865 ICSI cycles.

From: A comparison of menotropin, highly-purified menotropin and follitropin alfa in cycles of intracytoplasmic sperm injection

 

hMG

(n = 299)

HP-hMG

(n = 330)

r-hFSH

(n = 236)

p value

Mean length of stimulation, days (± SD)

9.6 (± 1.3)a

10.0 (± 1.3)b

10.1 (± 1.0)c

< 0.001

(a vs b, c)

   ≤35 years

9.5 (± 1.3)a

9.9 (± 1.2)b

10.0 (± 0.9)c

< 0.001

(a vs b, c)

   >35 years

9.8 (± 1.4)a

10.2 (± 1.6)b

10.2 (± 1.1)c

0.007

(a vs b, c)

Gonadotropin dose adjustment, n (%)

56 (18.7)a

67 (20.3)b

126 (53.4)c

< 0.001

(c vs a, b)

   ≤35 years

43 (20.1)a

47 (23.7)b

90 (63.3)c

< 0.001

(c vs a, b)

   >35 years

13 (15.1)a

20 (15.1)b

36 (38.2)c

< 0.001

(c vs a, b)

Mean estradiol on day of hCG, pg/mL (± SD)

1967.0

(± 1241.0)a

2479.0

(± 1708.0)b

2159.3 (± 1411.7)c

0.001

(a vs b, c)

   ≤35 years

2174.8

(± 1224.4)a

2609.3

(± 1632.0)b

2392.3

(± 1422.3)c

0.035

(a vs b)

   >35 years

1432.7

(± 1124.6)a

2285.1

(± 1804.4)b

1789.1

(± 1325.7)c

0.001

(a vs b)

Cancellation rate, n (%)

23 (7.7)

21 (6.4)

17 (7.2)

0.80

   ≤35 years

10 (4.7)

9 (4.5)

10 (7.0)

0.50

   >35 years

13 (15.1)

12 (9.0)

7 (7.4)

0.20

Severe OHSS, n (%)

7 (2.3)

6 (1.8)

3 (1.3)

0.76

   ≤35 years, n

5

4

3

-

   >35 years, n

2

2

0

-

Mean number of retrieved oocytes, n (± SD)

10.9 (± 6.8)

10.7 (± 6.5)

10.8 (± 6.7)

0.97

   ≤35 years

12.3 (± 6.7)

11.3 (± 5.5)

11.7 (± 6.0)

0.50

   >35 years

7.5 (± 5.8)

9.7 (± 7.6)

9.5 (± 7.5)

0.08

Mean MII oocytes, n (± SD)

8.9 (± 5.6)

8.9 (± 5.7)

8.7 (± 5.6)

0.82

   ≤35 years

10.1 (± 5.5)

9.4 (± 4.8)

9.1 (± 5.0)

0.20

   >35 years

5.8 (± 4.4)a

8.3 (± 6.8)b

8.1 (± 6.3)c

0.01

(a vs b, c)

Fertilization rate 2PN, % (± SD)

72 (± 25)

72 (± 22)

71 (± 23)

0.83

   ≤35 years

71 (± 22)

72 (± 22)

72 (± 22)

0.76

   >35 years

73 (± 30)

72 (± 24)

70 (± 25)

0.20

Top quality embryos on day3, % (± SD)

40 (± 30)a

47 (± 31)b

39 (± 29)c

0.004

(b vs a, c)

   ≤35 years

41 (± 29)a

47 (± 28)b

39 (± 28)c

0.03

(b vs a, c)

   >35 years

39 (± 34)

48 (± 34)

37 (± 30)

0.08

Mean number of transferred embryos, n (± SD)

3.4 (± 1.6)

3.4 (± 1.5)

3.2 (± 1.6)

0.18

   ≤35 years

3.5 (± 1.4)

3.5 (± 1.4)

3.2 (± 1.4)

0.05

   >35 years

2.9 (± 1.9)

3.1 (± 1.6)

3.2 (± 1.8)

0.50

  1. Distribution by menotropin (hMG), highly-purified menotropin (HP-hMG) or follitropin alfa (r-hFSH) for COH. Overall and age-stratified outcomes are presented.
  2. 2PN, two pronuclei; COH, controlled ovarian hyperstimulation; human chorionic gonadotropin; hMG, human menopausal gonadotropin; HP-hMG, highly-purified hMG; ICSI, intracytoplasmic sperm injection; MII, metaphase II; OHSS, ovarian hyperstimulation syndrome; r-hFSH, recombinant human follicle-stimulating hormone; SD, standard deviation.