Di-(2 ethylhexyl) phthalate and flutamide alter gene expression in the testis of immature male rats

Vo, Thuy TB; Jung, Eui-Man; Dang, Vu Hoang; Yoo, Yeong-Min; Choi, Kyung-Chul; Yu, Frank H; Jeung, Eui-Bae

doi:10.1186/1477-7827-7-104

Reproductive Biology and Endocrinology

Table 3 Down-regulated gene induced by TP, DEHP and Flu in the immature rat testes.

From: Di-(2 ethylhexyl) phthalate and flutamide alter gene expression in the testis of immature male rats

Transcript ID	Gene Symbol	Gene Name	Fold change (compared with VE)
			vs TP	vs DEHP 100	vs Flu 10
TP DOWN
NM_001012225	Mgat4a	Mannoside acetylglucosaminyltransferase 4, isoenzyme A	0.30	0.69	0.74
XM_214360	Ubxd6_predicted	UBX domain containing 6 (predicted)	0.35	0.82	0.63
XM_342534	Nat5_predicted	N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae) (predicted)	0.39	0.77	1.03
NM_053356	Col1a2	procollagen, type I, alpha 2	0.42	0.81	0.79
XM_345107	RGD1559810_predicted	similar to hypothetical protein (predicted)	0.42	0.83	0.77
NM_133317	Tob1	transducer of ErbB-2.1	0.43	0.82	1.04
XM_341903	Nrip3_predicted	nuclear receptor interacting protein 3 (predicted)	0.44	1.90	1.87
XM_229139	RGD1566225_predicted	similar to RIKEN cDNA 1700001F22 (predicted)	0.44	1.00	0.82
NM_001013185	Cabc1	chaperone, ABC1 activity of bc1 complex like (S. pombe)	0.45	1.08	0.73
XM_235640	Tmem16f_predicted	transmembrane protein 16F (predicted)	0.46	0.87	0.68
NM_001010966	Pigv	phosphatidylinositol glycan, class V	0.49	2.21	1.73
NM_133318	Khdrbs2	KH domain containing, RNA binding, signal transduction associated 2	0.49	0.82	0.85
DEHP DOWN
XM_218447	RGD1561121_predicted	similar to pleckstrin homology-like domain, family B, member 3 (predicted)	1.26	0.12	0.99
NM_199092	Orc4l	origin recognition complex, subunit 4-like (S. cerevisiae)	0.70	0.40	0.72
NM_031753	Alcam	activated leukocyte cell adhesion molecule	0.75	0.46	0.80
NM_001014242	Isoc1*	isochorismatase domain containing 1	0.85	0.46	0.90
XM_215497	Rad1_predicted	RAD1 homolog (S. pombe) (predicted)	0.97	0.46	0.86
XM_575065	RGD1559623_predicted	similar to RIKEN cDNA 5230400J09 (predicted)	0.93	0.48	0.69
NM_139189	Lmbrd1	LMBR1 domain containing 1	0.76	0.48	0.74
XM_236578	RGD1562949_predicted	similar to mKIAA0259 protein (predicted)	0.91	0.49	1.26
XM_215487	Mrps30_predicted	mitochondrial ribosomal protein S30 (predicted)	0.90	0.49	0.76
Flu DOWN
NM_001000234	Olr297_predicted	olfactory receptor 297 (predicted)	1.02	1.54	0.25
XM_236348	Cilp_predicted	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase (predicted)	0.65	0.89	0.40
XM_228462	RGD1565441_predicted	similar to KIAA1687 protein (predicted)	0.90	1.02	0.43
XM_219296	Rbbp6	retinoblastoma binding protein 6	0.65	0.82	0.45
NM_021653	Dio1	deiodinase, iodothyronine, type I	0.97	0.97	0.46

Altered gene down-regulation expression was estimated by the ratio of TP, DEHP 100 mg/kg BW/day and Flu 10 mg/kg BW/day treated vs. control as follows.
*, These altered genes were selected for verification by real- time PCR.

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ISSN: 1477-7827

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