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Table 2 Up-regulated gene induced by TP, DEHP and Flu in the immature rat testes.

From: Di-(2 ethylhexyl) phthalate and flutamide alter gene expression in the testis of immature male rats

Transcript ID Gene Symbol Gene Name Fold change (compared with VE)
    vs TP vs DEHP 100 vs Flu 10
TP UP      
XM_345848 Scrt1_predicted scratch homolog 1, zinc finger protein (Drosophila) 5.88 1.84 1.46
XM_213394 Tmem93_predicted transmembrane protein 93 (predicted) 5.07 1.49 1.43
XM_215951 Kcng1 potassium voltage-gated channel, subfamily G, member 1 3.07 1.13 0.96
NM_001008295 Fip1l1 FIP1 like 1 (S. cerevisiae) 2.44 1.00 1.08
NM_021669 Ghrl ghrelin precursor 2.37 1.02 1.00
XM_221387 Etv5_predicted ets variant gene 5 (ets-related molecule) (predicted) 2.14 1.01 1.13
XM_215635 Apoa1bp_predicted apolipoprotein A-I binding protein (predicted) 2.11 1.31 1.22
NM_031802 Gabbr2 gamma-aminobutyric acid (GABA) B receptor 2 2.06 1.29 0.80
NM_133529 Cabp1* calcium binding protein 1 2.05 1.11 0.97
XM_216030 Vav2* Vav2 oncogene (predicted) 1.77 1.41 1.11
DEHP UP      
XM_213289 RGD1308066_predicted similar to KIAA1960 protein (predicted) 0.99 3.29 1.64
NM_012616 Omp olfactory marker protein 1.07 3.08 1.19
NM_021590 Aipl1 aryl hydrocarbon receptor-interacting protein-like 1 1.31 2.91 1.22
NM_031770 Gnb5 guanine nucleotide binding protein, beta 5 1.14 2.65 1.10
NM_001000980 Olr1366 olfactory receptor 1366 1.33 2.62 1.16
NM_022625 Tpc1808 tropic 1808 1.11 2.43 1.36
NM_001014015 Rbm34 RNA binding motif protein 34 1.28 2.43 1.22
NM_199291 Doxl2 diamine oxidase-like protein 2 1.27 2.42 1.01
XM_220283 Sox8_predicted SRY-box containing gene 8 (predicted) 1.10 2.33 1.18
NM_023992 Kiss1r KISS1 receptor 1.12 2.31 1.24
NM_001000365 Olr748_predicted olfactory receptor 748 (predicted) 1.21 2.30 1.26
NM_017035 Plcd1* phospholipase C, delta 1 1.20 2.20 1.24
XM_221627 Brwd1_predicted bromodomain and WD repeat domain containing 1 (predicted) 1.30 2.19 1.18
XM_221521 Hoxd4_predicted homeo box D4 (predicted) 0.67 2.17 0.93
XM_344627 Calm4_predicted calmodulin 4 (predicted) 1.08 2.16 0.84
XM_216225 Ppp4r2_predicted protein phosphatase 4, regulatory subunit 2 (predicted) 1.22 2.15 1.45
NM_175587 Taar7h trace-amine-associated receptor 7 h 1.14 2.14 1.11
NM_020106 Olr414_predicted olfactory receptor 414 (predicted) 1.35 2.13 0.94
NM_145880 Lhx1* LIM homeobox protein 1 1.04 1.72 1.20
Flu UP      
XM_575355 RGD1561053_predicted similar to Claudin 12 (predicted) 1.49 1.16 3.18
XM_218187 Cnot3_predicted CCR4-NOT transcription complex, subunit 3 (predicted) 1.21 1.10 2.48
NM_012992 Npm1 nucleophosmin 1 1.31 1.13 2.25
NM_017265 Hsd3b1* hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.87 0.97 2.18
XM_214673 Cog8_predicted component of oligomeric golgi complex 8 (predicted) 0.75 0.79 2.07
XM_225336 Lrrc16_predicted leucine rich repeat containing 16 (predicted) 1.00 1.31 2.06
XM_226843 Rnasen ribonuclease III, nuclear 0.93 0.69 2.05
XM_234056 RGD1564242_predicted similar to KIAA1218 protein (predicted) 0.97 1.02 2.05
NM_013175 Sgne1 secretory granule neuroendocrine protein 1 0.83 0.81 2.04
XM_221047 Polg2_predicted polymerase (DNA directed), gamma 2, accessory subunit (predicted) 1.14 1.05 2.01
  1. The cDNA microarray analysis for detection of fold changes of gene expression in the testis of immature rats following treatments with TP, DEHP or Flu.
  2. Altered gene up-regulation expression was estimated by the ratio of TP, DEHP 100 mg/kg BW/day and Flu 10 mg/kg BW/day treated vs. control as follows.
  3. *, These altered genes were selected for verification by real- time PCR.