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Figure 5 | Reproductive Biology and Endocrinology

Figure 5

From: Epidermal growth factor mediates spermatogonial proliferation in newt testis

Figure 5

Dose-dependent effects of inhibitors for MAPK and PI3K on EGF-stimulated spermatogonial proliferation. Testicular fragments containing spermatogonial stage treated without (0) or with various doses of a MAPK-specific inhibitor (PD98059) (A) or PI3K-specific inhibitors (Wortmannin (B) and LY294002 (C)), were cultured for 1 week in the absence (Control) or presence of either FSH (200 ng/μl) or EGF (4000 ng/μl), followed by BrdU incorporation assay. *, P < 0.05; **, P < 0.01.

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